In the Clinic is a monthly feature in Annals of Internal Medicine introduced in January 2007 that focuses on practical management of patients with common clinical conditions. It offers evidence-based answers to frequently asked questions about screening, prevention, diagnosis, therapy, and patient education and provides physicians with tools to improve the quality of care across settings of care—from screening and prevention in the primary care setting to care of hospitalized patients.

With the assistance of additional physician writers, the editors of Annals of Internal Medicine develop In the Clinic using the best available evidence, including MKSAP and other resources of the American College of Physicians.