Population Immunity Against COVID-19 in the United StatesFREE
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Visual Abstract. Population Immunity Against COVID-19 in the United States.
Much attention has been given to vaccination as a path to achieving herd immunity against COVID-19, but immunity is gained from both natural infection and vaccination. In this study, the authors used statistical and simulation modeling and data on reported deaths to estimate U.S. population immunity.
Abstract
Background:
As of 28 July 2021, 60% of adults in the United States had been fully vaccinated against COVID-19, and more than 34 million cases had been reported. Given the uncertainty regarding undocumented infections, the population level of immunity against COVID-19 in the United States remains undetermined.
Objective:
To estimate the population immunity, defined as the proportion of the population that is protected against SARS-CoV-2 infection due to prior infection or vaccination.
Design:
Statistical and simulation modeling to estimate overall and age-specific population immunity.
Setting:
United States.
Participants:
Simulated age-stratified population representing U.S. demographic characteristics.
Measurements:
The true number of SARS-CoV-2 infections in the United States was inferred from data on reported deaths using age-specific infection-fatality rates (IFRs). Taking into account the estimates for vaccine effectiveness and protection against reinfection, the overall population immunity was determined as the sum of protection levels in vaccinated persons and those who were previously infected but not vaccinated.
Results:
Using age-specific IFR estimates from the Centers for Disease Control and Prevention, it was estimated that as of 15 July 2021, 114.9 (95% credible interval [CrI], 103.2 to 127.4) million persons had been infected with SARS-CoV-2 in the United States. The mean overall population immunity was 62.0% (CrI, 58.4% to 66.4%). Adults aged 65 years or older were estimated to have the highest immunity level (77.2% [CrI, 76.2% to 78.6%]), and children younger than 12 years had the lowest immunity level (17.9% [CrI, 14.4% to 21.9%]).
Limitation:
Publicly reported deaths may underrepresent actual deaths.
Conclusion:
As of 15 July 2021, the U.S. population immunity against COVID-19 may still have been insufficient to contain the outbreaks and safely revert to prepandemic social behavior.
Primary Funding Source:
National Science Foundation, National Institutes of Health, Notsew Orm Sands Foundation, Canadian Institutes of Health Research, and Natural Sciences and Engineering Research Council of Canada.
Population immunity against COVID-19 through a combination of vaccination and infection is fundamental to epidemiologic trajectories, the potential for emerging variants to spread, and the likelihood of disease control. In the United States, as of 28 July 2021, more than 34 million COVID-19 cases had been reported since the beginning of the pandemic. Vaccine development and deployment have proceeded rapidly, and more than 340 million doses have been administered, with 60% of the adult population fully vaccinated. Concurrently, the daily number of new cases has decreased dramatically since the peak of the pandemic in January 2021, although population pockets with low vaccination coverage are experiencing upticks in cases as the highly contagious Delta (B.1.617.2) variant spreads across the United States. The lack of adherence to nonpharmaceutical interventions before attainment of sufficient population immunity carries a significant risk for another wave of COVID-19 cases and deaths.
Previous studies and news reports have primarily focused on vaccination as a path to achieving herd immunity (1–3). However, immunity in the population is gained from both natural infection and vaccination. Given the uncertainty about unreported cases, including asymptomatic infections, questions remain about the true number of infections throughout the pandemic and the level of population immunity achieved in the United States thus far. In this study, we estimated overall and age-specific levels of population immunity against COVID-19 in the United States.
Methods
Model Overview
We used statistical and simulation modeling as well as reported deaths in the United States to estimate the total number of infections since the start of the pandemic. We then combined these with estimates of vaccination coverage and real-world vaccine effectiveness to calculate the overall and age-stratified population immunity in the United States. Simulation codes for reproducibility can be found at https://github.com/affans/c19popimmunity.
Data Sources
We used reported daily COVID-19 deaths for each age group (4, 5) in the United States from 21 January 2020 to 15 July 2021. Information on coverage of first and second vaccine doses, stratified by age groups, was obtained from the Centers for Disease Control and Prevention (CDC) (6). Infection-fatality rate (IFR) estimates and other data inputs were obtained from published literature and the CDC (Tables 1 to 3).
Estimating Total Infections
The total number of infections was estimated from reported daily COVID-19 deaths in the United States (4, 5) using 500 Monte Carlo simulations. Specifically, the reported death total Dt on each day t was used to impute the number of infections, using estimates of the IFR for COVID-19. The IFR, by definition, represents the ratio of the cumulative deaths attributable to the disease to the total number of infections (both symptomatic and asymptomatic). To account for the uncertainty in IFR estimates, we sampled IFR values for model inputs from age-specific log-normal distributions, with the mean parameters informed by estimates from 3 sources: the CDC (7), an analysis of the early stages of the pandemic in China (8), and a multinational study combining death data from 45 countries and the results of 22 seroprevalence studies (9) (Table 1). The scale parameter of the log-normal distributions was set to 0.1, which allowed for the range of IFR estimates to be considered in the model sampling. The number of infections Nt in each age group was then calculated as Dt / IFR.
Accounting for the Lag Time Between Infection and Death
For each inferred infection, whether it resulted in recovery or death, we estimated the lag time t′ so that the infection occurred t − t′ days before the reported death on day t. The lag time was calculated as the sum of 2 independent intervals: the incubation period, which estimates the time from infection to onset of symptoms, and the time from symptom onset to death (Table 2). These intervals were sampled for each infection, accounting for the uncertainty of parameters in their corresponding distributions. The number of infections Nτ on any day τ was then calculated as the sum of all infections associated with reported deaths at time t > τ and all infection lag times t′ such that t − t′ = τ.
Adjustment for Double-Counting
To prevent double-counting in our estimates of population immunity, we derived the proportion P of previously infected persons who were vaccinated (Table 3). In the absence of information on prior infection for vaccinated persons, we probabilistically calculated the proportion P for each age group via Monte Carlo replications. In each replication, we randomly assigned infections to a computational vector of population size for each age group, corresponding to the cumulative number of infections inferred from the process described earlier. Similarly, fully vaccinated persons were assigned randomly to a vector of the same size, according to the reported vaccination coverage of the age group. We then determined the overlap between these vectors to identify persons who were both vaccinated and infected. We iterated this process 1000 times to obtain the mean and the lower and upper bounds of the proportion P and to determine the number of persons who were infected but not vaccinated. Given the CDC's recommendation to delay vaccination by 3 months after infection, this part of the analysis was done for those who were infected 90 days before 15 July 2021 (16).
Analysis of Population Immunity
We estimated the naturally acquired protection level by adjusting the cumulative number of infections ΣNτ for the level of protection against reinfection conferred by a previous infection (Table 2). For vaccine-induced population immunity, we considered the proportion of vaccinated persons who received the Pfizer-BioNTech (58%) and Moderna (42%) vaccines (17) and effectiveness after the first and second doses of each (Table 2). We calculated population immunity as the sum of naturally acquired protection levels in previously infected but unvaccinated persons and levels of vaccine-induced protection in partially and fully vaccinated persons.
Sensitivity Analyses
Given the variation in IFRs due to population heterogeneity and seroprevalence studies, we also considered IFR estimates from 2 other studies to inform our calculations of the overall population immunity (Table 1). First, we used IFR estimates derived from individual-level data for patients who died of COVID-19 in Hubei, China, during the early stages of the pandemic (8). We then used more recent IFR values that relied on age-specific data on COVID-19–attributable death from national-level seroprevalence surveys (9).
To account for uncertainty in vaccine effectiveness against infection and naturally acquired protection against reinfection, we performed 500 Monte Carlo simulations that accounted for confidence intervals around these estimates. The credible intervals (CrIs) around population immunity levels were obtained by performing 500 Monte Carlo simulations to account for uncertainty around input parameters.
Role of the Funding Source
The funding sources had no role in the design of the study, collection and analysis of the data, interpretation of the results, or the decision to publish the manuscript.
Results
Primary Analysis
Using IFR estimates reported by the CDC (Table 1), we calculated that as of 15 July 2021, 114.9 (95% CrI, 103.2 to 127.4) million people had been infected with SARS-CoV-2 in the United States (Figure 1), which is 3.38 times higher than the reported number of cases (18). Accounting for an average of 80.5% protection against reinfection (6, 10) and vaccine-specific protections against infection in partially and fully vaccinated persons (8, 9), we estimated a mean overall population immunity of 62.0% (CrI, 58.4% to 66.4%) (Figure 2). Adults aged 65 years or older were estimated to have the highest level of immunity (77.2% [CrI, 76.2% to 78.6%]), followed by adults aged 18 to 49 years (72.7% [CrI, 67.6% to 79.0%]) and those aged 50 to 64 years (70.6% [CrI, 67.7% to 74.3%]). Immunity was substantially lower among adolescents aged 12 to 17 years (37.9% [CrI, 34.8% to 41.9%]) and children younger than 12 years (17.9% [CrI, 14.4% to 21.9%]) (Figure 2).
Figure 1. Estimated number of SARS-CoV-2 infections in the United States as of 15 July 2021, using estimates of IFR from the CDC (7).
The solid curve indicates the estimated cumulative number of infections, and the shaded area represents the 95% credible interval. The dotted curve represents the cumulative infections reported by the CDC as of 15 July 2021. CDC = Centers for Disease Control and Prevention; IFR = infection-fatality rate.
Figure 2. Estimated age-specific and overall population immunity against SARS-CoV-2 infection as of 15 July 2021, using estimates of infection-fatality rate from the Centers for Disease Control and Prevention (7).
The bars represent 95% credible intervals.
Sensitivity Analyses
When considering IFR values derived from the early stages of the pandemic in the model (8), we obtained 91.48 (CrI, 82.94 to 100.77) million infections, which is 26% lower than the number calculated by applying the CDC IFR estimates in the model (Appendix Figure 1). The highest and lowest immunity were associated with persons aged 65 years or older and children younger than 12 years, respectively. The overall population immunity was estimated to be 58.3% (CrI, 55.3% to 62.1%). However, when IFR values estimated from multiple seroprevalence studies were used (9), the total number of infections in the United States was 163.68 (CrI, 147.47 to 180.78) million, and the overall population immunity increased to 66.7% (CrI, 62.3% to 71.7%) (Appendix Figure 2). The patterns of age-specific immunity remained similar to those derived using IFR estimates from the CDC, with the highest immunity in persons aged 65 years or older (82.5% [CrI, 79.9% to 85.7%]) and the lowest immunity among children younger than 12 years (17.9% [CrI, 14.5% to 21.8%]).
Appendix Figure 1. Estimated number of infections and population immunity against SARS-CoV-2 infection in the United States as of 15 July 2021, using early estimates of infection-fatality rate (8).
Top. Cumulative number of infections (solid curve) and 95% credible intervals (shaded area). The dotted curve represents the cumulative infections reported by the Centers for Disease Control and Prevention. Bottom. Estimates of age-specific and overall population immunity. The bars represent 95% credible intervals.
Appendix Figure 2. Estimated number of infections and population immunity against SARS-CoV-2 infection in the United States as of 15 July 2021, using recent estimates of infection-fatality rate (9).
Top. Cumulative number of infections (solid curve) and 95% credible intervals (shaded area). The dotted curve represents the cumulative infections reported by the Centers for Disease Control and Prevention. Bottom. Estimates of age-specific and overall population immunity. The bars represent 95% credible intervals.
These estimates were calculated using the reported mean vaccine effectiveness and the level of naturally acquired protection against reinfection. When we accounted for the confidence intervals of these protection levels and considered the 3 sources of IFR values, the average population immunity ranged from 52.1% to 71.0% (Figure 3).
Figure 3. Estimated population immunity as of 15 July 2021, using IFR values from 3 sources (Table 1 ), with the low and high bounds of VE against infection ( x -axis) (14, 15) and reinfection (6, 10).
The bars correspond to the lower and upper bounds of confidence intervals for VE and naturally acquired protection against infection. CDC = Centers for Disease Control and Prevention; IFR = infection-fatality rate; VE = vaccine effectiveness.
Discussion
Using age-stratified IFR estimates reported by the CDC, we calculated that as of 15 July 2021, 114.9 (CrI, 103.2 to 127.4) million SARS-CoV-2 infections had occurred in the United States. The range of our estimate overlaps the most recent CDC estimate of 120.2 million infections, which was derived from a statistical model applied to confirmed COVID-19 cases (19). When we considered all sources of IFR values in our analysis and used mean estimates of vaccine-induced and naturally acquired protection levels, the average population immunity ranged from 58.3% to 66.7%. Variants of SARS-CoV-2 with higher transmissibility, such as the Delta variant (20), will inevitably increase levels of naturally acquired immunity, but at the cost of potentially increased severe health outcomes. Improving daily vaccination rates would accelerate the increase in population immunity and reduce hospitalizations and deaths, even if infection occurs with lower vaccine effectiveness against immune-evading variants (21, 22). Given the large geographic variation and clustering in immunity, regions with low vaccination coverage will continue to experience local outbreaks and continuously disseminate infections to other regions, prolonging the COVID-19 pandemic in the United States.
Our study has limitations. First, our estimates of population immunity are based on the reported effectiveness of the Pfizer-BioNTech and Moderna vaccines, which constitute 96% of all doses administered in the United States (17). However, we note that the single-dose Johnson & Johnson vaccine authorized for emergency use in the United States has slightly lower effectiveness than the Pfizer-BioNTech and Moderna vaccines (23, 24). Second, we assumed that all persons with prior infection have a mean protection level of 80.5% against reinfection (6, 10) and performed sensitivity analyses on the estimated range (Figure 3). However, this protection can be age-dependent, decreasing to approximately 47% for persons aged 65 years or older (6). Third, to determine the proportion of previously infected persons who were also vaccinated, we assumed that the decision to be vaccinated was independent of prior infection. Fourth, vaccine-induced protection may be lower for immune-evading variants, such as the Delta variant, than for the original SARS-CoV-2 strain (22). Finally, we used daily deaths reported by the CDC to calculate the total number of infections. Recent estimates indicate that 24% of the total deaths attributable to COVID-19 in the United States have not been reported (25, 26), of which more than a third have occurred among persons aged 80 years or older. Although the unreported deaths may skew our estimates toward lower population immunity, IFR estimates are also subject to similar constraints, minimizing the potential bias in our estimates. Moreover, any underestimation of population immunity would further underscore the gap between population immunity and herd immunity thresholds that must be achieved to reverse the pandemic trajectory. In addition, vaccination and infection rates vary by location. For example, many states in the Northeast have achieved high vaccination coverage and low infection rates, whereas certain areas of the South and Midwest have relatively low vaccination and high infection rates.
Our study highlights the need to accelerate vaccination to prevent additional waves of COVID-19 and the evolution of novel variants and to shorten timelines for pandemic control in the United States. Adherence to nonpharmaceutical interventions, such as face masks and proactive testing, should be encouraged at least until population immunity is sufficiently high to contain the pandemic.
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Information & Authors
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Published In
Annals of Internal Medicine
Volume 174 • Number 11 • November 2021
Pages: 1586 - 1591
History
Published online: 14 September 2021
Published in issue: November 2021
Keywords
Copyright
© 2021 American College of Physicians.
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Population Immunity Against COVID-19 in the United States. Ann Intern Med.2021;174:1586-1591. [Epub 14 September 2021]. doi:10.7326/M21-2721
Population Immunity Against COVID-19 in the United States. Ann Intern Med.2021;174:1586-1591. [Epub 14 September 2021]. doi:10.7326/M21-2721
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