Editorials1 March 2022
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    Nearly 60 years after the development of modern screening mammography, the issue of overdiagnosis from breast cancer screening remains controversial. This controversy is driven both by disciplinary differences in the definition of overdiagnosis and uncertainty about the probability of overdiagnosis. Ryser and colleagues' article offers an important step forward in addressing the latter concern (1). Using a natural history likelihood model based on data from the Breast Cancer Surveillance Consortium, the authors found that between 1 in 6 to 7 cases of cancer detected in a biennial screening program would not have manifested clinically in the woman's lifetime. These results ...