Research and Reporting Methods
14 May 2024

Reporting Conflicts of Interest and Funding in Health Care Guidelines: The RIGHT-COI&F Checklist

Publication: Annals of Internal Medicine
Volume 177, Number 6

Abstract

Background:

Conflicts of interest (COIs) of contributors to a guideline project and the funding of that project can influence the development of the guideline. Comprehensive reporting of information on COIs and funding is essential for the transparency and credibility of guidelines.

Objective:

To develop an extension of the Reporting Items for practice Guidelines in HealThcare (RIGHT) statement for the reporting of COIs and funding in policy documents of guideline organizations and in guidelines: the RIGHT-COI&F checklist.

Design:

The recommendations of the Enhancing the QUAlity and Transparency Of health Research (EQUATOR) network were followed. The process consisted of registration of the project and setting up working groups, generation of the initial list of items, achieving consensus on the items, and formulating and testing the final checklist.

Setting:

International collaboration.

Participants:

44 experts.

Measurements:

Consensus on checklist items.

Results:

The checklist contains 27 items: 18 about the COIs of contributors and 9 about the funding of the guideline project. Of the 27 items, 16 are labeled as policy related because they address the reporting of COI and funding policies that apply across an organization’s guideline projects. These items should be described ideally in the organization’s policy documents, otherwise in the specific guideline. The remaining 11 items are labeled as implementation related and they address the reporting of COIs and funding of the specific guideline.

Limitation:

The RIGHT-COI&F checklist requires testing in real-life use.

Conclusion:

The RIGHT-COI&F checklist can be used to guide the reporting of COIs and funding in guideline development and to assess the completeness of reporting in published guidelines and policy documents.

Primary Funding Source:

The Fundamental Research Funds for the Central Universities of China.

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Supplemental Material

Supplementary Figures and the List of Working Group Members
Comments and Median Scores From the Expert Panel With Responses and Suggested Revisions
Summary of Feedback Given During the Consensus Meetings With Responses From the Coordination Team
The Extension of the RIGHT Statement for Reporting Conflicts of Interest and Funding in Practice Guidelines: Explanation and Elaboration

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Information & Authors

Information

Published In

cover image Annals of Internal Medicine
Annals of Internal Medicine
Volume 177Number 6June 2024
Pages: 782 - 790

History

Published online: 14 May 2024
Published in issue: June 2024

Keywords

Authors

Affiliations

School of Basic Medical Sciences, Lanzhou University, Gansu, and School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (Y.X.)
Janne Estill, PhD
School of Basic Medical Sciences, Lanzhou University, Gansu, China, and Institute of Global Health, University of Geneva, Geneva, Switzerland (J.E.)
Joanne Khabsa, BS Pharm, MPH https://orcid.org/0000-0002-4336-3501
Clinical Research Institute, American University of Beirut Medical Center, Beirut, Lebanon (J.K.)
Ivan D. Florez, MD, MSc, PhD https://orcid.org/0000-0002-0751-8932
Department of Pediatrics, University of Antioquia, and Pediatric Intensive Care Unit, Clínica Las Americas-AUNA, Medellin, Colombia, and School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada (I.D.F.)
Department of Health Research Methods, Evidence and Impact (HEI), McMaster University, Hamilton, Ontario, Canada (G.H.G., H.J.S.)
Susan L. Norris, MD, MPH https://orcid.org/0000-0002-0042-2452
Oregon Health & Science University, Portland, Oregon (S.L.N.)
Clinical Research Division, Korea Institute of Oriental Medicine, Daejeon, South Korea (M.S.L.)
Akihiko Ozaki, MD, PhD
Department of Breast and Thyroid Surgery, Jyoban Hospital of Tokiwa Foundation, Iwaki City, Fukushima, Japan (A.O.)
Amir Qaseem, MD, PhD, MHA https://orcid.org/0000-0001-6866-7985
American College of Physicians, Philadelphia, Pennsylvania (A.Q.)
Holger J. Schünemann, MD, MSc, PhD https://orcid.org/0000-0003-3211-8479
Department of Health Research Methods, Evidence and Impact (HEI), McMaster University, Hamilton, Ontario, Canada (G.H.G., H.J.S.)
Ruitai Shao, MD, MPH, PhD https://orcid.org/0000-0003-1977-7445
School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (R.S.)
School of Basic Medical Sciences, Research Unit of Evidence Based Evaluation and Guidelines, Chinese Academy of Medical Sciences (2021RU017), Lanzhou University, and WHO Collaborating Centre for Guideline Implementation and Knowledge Translation, Gansu, China (Y.C.)
Elie A. Akl, MD, MPH, PhD https://orcid.org/0000-0002-3444-8618
Department of Internal Medicine, American University of Beirut, Beirut, Lebanon (E.A.A.).
RIGHT-COI&F Working Groups*
Note: Dr. Stephanie Chang, Deputy Editor for Annals, had no role in the editorial review of or decision to publish this article.
Acknowledgment: Members of the RIGHT-COI&F Working Groups who, in addition to the named authors, authored this work are: Yasser Sami Abdel Dayem Amer, Imad Bou Akl, Thurayya Arayssi, Pablo Alonso-Coello, Sarah Louise Barber, Stephanie Chang, Philipp Dahm, Yngve Falck-Ytter, Nathan Ford, Quinn Grundy, Glen S. Hazlewood, Akira Kuriyama, Andreas Lundh, Ana Marušić, Joseph L. Mathew, Barbara Mintzes, Reem Mustafa, David Fraile Navarro, Detty Nurdiati, Dawid Pieper, Hiroaki Saito, Yang Song, Renfeng Su, Rebekah Thomas, Ružica Tokalić, Marcello Tonelli, Ping Wang, Xu Wang, Zijun Wang, Nan Yang, and Di Zhu.
Financial Support: By the Fundamental Research Funds for the Central Universities (lzujbky-2021-ey13).
Reproducible Research Statement: Study protocol: Published (25). Statistical code: Not applicable. Data set: Full results of expert survey available in Supplement 2.
Corresponding Author: Yaolong Chen, MMed, PhD, Research Unit of Evidence Based Evaluation and Guidelines, Chinese Academy of Medical Sciences (2021RU017), School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Chengguan District, Lanzhou, Gansu, China 730000; e-mail, [email protected]; and Elie A. Akl, MD, MPH, PhD, Department of Internal Medicine, American University of Beirut Medical Center, PO Box 11-0236, Riad-El-Solh, Beirut 1107 2020; e-mail, [email protected].
Author Contributions: Conception and design: E.A. Akl, Y. Chen, B. Mintzes, S.L. Norris, A. Ozaki, A. Qaseem, H.J. Schünemann, R. Shao, Y. Song, Y. Xun, N. Yang.
Analysis and interpretation of the data: E.A. Akl, P. Alonso-Coello, T. Arayssi, I. Bou Akl, S. Chang, Y. Chen, J. Estill, I.D. Florez, Q. Grundy, G.H. Guyatt, G.S. Hazlewood, J. Khabsa, A. Kuriyama, A. Marušić, R. Mustafa, S.L. Norris, A. Ozaki, D. Pieper, H.J. Schünemann, Y. Song, R. Tokalić, Y. Xun, N. Yang.
Drafting of the article: E.A. Akl, Y.S.A.D. Amer, I. Bou Akl, N. Ford, J.L. Mathew, B. Mintzes, S.L. Norris, A. Qaseem, R. Shao, Y. Song, R. Tokalić, Y. Xun.
Critical revision of the article for important intellectual content: E.A. Akl, P. Alonso-Coello, Y.S.A.D. Amer, S. Chang, Y. Chen, P. Dahm, J. Estill, Y. Falck-Ytter, I.D. Florez, N. Ford, Q. Grundy, G.S. Hazlewood, J. Khabsa, A. Kuriyama, A. Lundh, A. Marušić, J.L. Mathew, B. Mintzes, R. Mustafa, S.L. Norris, D. Nurdiati, A. Ozaki, D. Pieper, A. Qaseem, H. Saito, H.J. Schünemann, R. Shao, Y. Song, R. Thomas, R. Tokalić, M. Tonelli, Y. Xun.
Final approval of the article: E.A. Akl, P. Alonso-Coello, Y.S.A.D. Amer, T. Arayssi, S.L. Barber, I. Bou Akl, S. Chang, Y. Chen, P. Dahm, J. Estill, Y. Falck-Ytter, I.D. Florez, N. Ford, D.F. Navarro, Q. Grundy, G.H. Guyatt, G.S. Hazlewood, J. Khabsa, A. Kuriyama, M.S. Lee, A. Lundh, A. Marušić, J.L. Mathew, B. Mintzes, R. Mustafa, S.L. Norris, D. Nurdiati, A. Ozaki, D. Pieper, A. Qaseem, H. Saito, H.J. Schünemann, R. Shao, Y. Song, R. Su, R. Thomas, R. Tokalić, M. Tonelli, P. Wang, X. Wang, Z. Wang, Y. Xun, N. Yang, D. Zhu.
Provision of study materials or patients: Y. Chen, I.D. Florez, M.S. Lee, Y. Xun.
Statistical expertise: J. Estill, A. Qaseem, R. Shao, Y. Xun.
Obtaining of funding: Y. Chen, R. Shao.
Administrative, technical, or logistic support: E.A. Akl, R. Su, R. Tokalić, Z. Wang, P. Wang, X. Wang, Y. Xun, D. Zhu.
Collection and assembly of data: E.A. Akl, S.L. Barber, J. Estill, Y. Falck-Ytter, I.D. Florez, A. Kuriyama, M.S. Lee, A. Lundh, S.L. Norris, A. Ozaki, H. Saito, Y. Song, R. Su, R. Tokalić, M. Tonelli, P. Wang, X. Wang, Z. Wang, Y. Xun, D. Zhu.
This article was published at Annals.org on 14 May 2024.
*
Members of the RIGHT-COI&F Working Groups are listed at the end of the article.

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Yangqin Xun, Janne Estill, Joanne Khabsa, et al; RIGHT-COI&F Working Groups. Reporting Conflicts of Interest and Funding in Health Care Guidelines: The RIGHT-COI&F Checklist. Ann Intern Med.2024;177:782-790. [Epub 14 May 2024]. doi:10.7326/M23-3274

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