Background: Although persistent opioid use after surgery, including cesarean birth, has been described, the risk for overdose and other serious opioid-related events (SOREs) after childbirth, specifically vaginal birth, remains unclear (1, 2).
Objective: To assess risk for SOREs associated with postpartum opioid prescribing after childbirth, including both vaginal and cesarean births.
Methods and Findings: We studied women aged 15 to 44 years enrolled in Tennessee Medicaid (TennCare) who were discharged after childbirth between 1 January 2007 and 20 August 2014. TennCare data were supplemented with birth certificate information and hospital discharge data from the Tennessee Hospital Discharge Data System. This ...
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Author, Article and Disclosure Information
Vanderbilt University Medical Center, Nashville, Tennessee (S.S.O., J.Y.M., A.D.W., R.E.H., E.M., S.W.P., L.R.S., M.R.G.)
Vanderbilt University Medical Center and Veterans Health Administration Tennessee Valley Healthcare System, Geriatric Research Education and Clinical Center (GRECC), Nashville, Tennessee (C.G.G.)
Note: Dr. Osmundson had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Disclaimer: The funders of the study had no role in the design of the study, analysis or interpretation of the data, or writing of the report. The corresponding author had final responsibility for the decision to submit the manuscript for publication.
Acknowledgment: The authors thank the Tennessee Division of TennCare of the Department of Finance and Administration and the Tennessee Department of Health for providing data for the study.
Financial Support: Dr. Osmundson was supported by grants K12HD04348317 from the National Institutes of Health and K23DA047476 from the National Institute on Drug Abuse. Dr. Min was supported by the Veterans Affairs Office of Academic Affiliations. Dr. Wiese was supported by the Vanderbilt Faculty Research Scholars program and a PhRMA Foundation Fellowship in Health Outcomes. Dr. Patrick was supported by grant K23DA038720 from the National Institute on Drug Abuse. The study was supported in part by the National Institutes of Health, National Institute on Aging, through grant R01AG043471.
Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M19-3805.
Reproducible Research Statement: Study protocol and statistical code: Available from Dr. Osmundson (e-mail, sarah.
Corresponding Author: Sarah S. Osmundson, MD, MS, 1161 21st Avenue, South B1118 MCN, Nashville, TN 37232; e-mail, sarah.
This article was published at Annals.org on 9 June 2020.
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