Substantial progress has been made during the past 20 years in pregnancy management and outcomes in women with systemic lupus erythematosus (SLE), as Mehta and colleagues show in their current article in Annals (1). Thirty years ago, most women with SLE were advised to avoid pregnancy because of high risks for maternal and fetal morbidity and mortality. Now, this advice has shifted entirely, and most women with SLE, with careful management, can safely build a family thanks to several developments.

Many prospective cohorts of pregnant women with SLE have demonstrated that disease activity in the months before and during pregnancy ...


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