EditorialsAugust 15, 2017
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The reduction in cardiovascular morbidity and mortality during the past 3 decades represents one of the great triumphs of contemporary medicine. In 1987, the age-adjusted mortality rate in the U.S. population for cardiovascular disease was 357 in 100 000, decreasing to 167 in 100 000 by 2014 (1). Although precisely gauging the relative contributions of various public health measures to the decline in cardiovascular morbidity and mortality is impossible, most critical observers consider the introduction of statins in 1987 to be one of the keys to this success. According to the Centers for Disease Control and Prevention, the prevalence of elevated low-density ...

References

  • 1. Weir HK Anderson RN ColemanKing SM Soman A Thompson TD Hong Y et alHeart disease and cancer deaths—trends and projections in the United States, 1969–2020. Prev Chronic Dis2016;13:E157. [PMID: 27854420] doi:10.5888/pcd13.160211 CrossrefMedlineGoogle Scholar
  • 2. Rosinger A Carroll MD Lacher D , and  Ogden C Trends in total cholesterol, triglycerides, and low-density lipoprotein in US adults, 1999–2014. JAMA Cardiol2017;2:339-341. [PMID: 27902824] doi:10.1001/jamacardio.2016.4396 CrossrefMedlineGoogle Scholar
  • 3. Pencina MJ Navar-Boggan AM D'Agostino RB Sr Williams K Neely B Sniderman AD et alApplication of new cholesterol guidelines to a population-based sample. N Engl J Med2014;370:1422-31. [PMID: 24645848] doi:10.1056/NEJMoa1315665 CrossrefMedlineGoogle Scholar
  • 4. Guglielmi V Bellia A Pecchioli S Della-Morte D Parretti D Cricelli I et alEffectiveness of adherence to lipid lowering therapy on LDL-cholesterol in patients with very high cardiovascular risk: a real-world evidence study in primary care. Atherosclerosis2017;263:36-41. [PMID: 28599257] doi:10.1016/j.atherosclerosis.2017.05.018 CrossrefMedlineGoogle Scholar
  • 5. Colantonio LD Huang L Monda KL Bittner V Serban MC Taylor B et alAdherence to high-intensity statins following a myocardial infarction hospitalization among Medicare beneficiaries. JAMA Cardiol2017. [PMID: 28423147] doi:10.1001/jamacardio.2017.0911 CrossrefMedlineGoogle Scholar
  • 6. Alliance for Natural Health USA. The Pulse of Natural Health Newsletter. 14 July 2015. Accessed at www.anh-usa.org/the-grave-dangers-of-statin-drugs-and-the-surprising-benefits-of-cholesterol/ on 20 June 2017. Google Scholar
  • 7. Nissen SE Stroes E Dent-Acosta RE Rosenson RS Lehman SJ Sattar N et alGAUSS-3 InvestigatorsEfficacy and tolerability of evolocumab vs ezetimibe in patients with muscle-related statin intolerance: the GAUSS-3 randomized clinical trial. JAMA2016;315:1580-90. [PMID: 27039291] doi:10.1001/jama.2016.3608 CrossrefMedlineGoogle Scholar
  • 8. Zhang H Plutzky J Shubina M , and  Turchin A Continued statin prescriptions after adverse reactions and patient outcomes. A cohort study. Ann Intern Med2017;167:221-7. doi:10.7326/M16-0838 LinkGoogle Scholar
  • 9. De Vera MA Bhole V Burns LC , and  Lacaille D Impact of statin adherence on cardiovascular disease and mortality outcomes: a systematic review. Br J Clin Pharmacol2014;78:684-98. [PMID: 25364801] CrossrefMedlineGoogle Scholar
  • 10. The Dr. Oz Show. Reverse your heart disease in 28 days. Accessed at www.doctoroz.com/article/reverse-your-heart-disease-28-days on 20 June 2017. Google Scholar