Editorials15 August 2017
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    Coffee is one of the most frequently consumed beverages worldwide. In the United States, about 75% of adults drink coffee, and 50% drink it daily (1). Coffee is a major source of caffeine, with wide variation in the amount among different types of coffee (8 mg of caffeine per fluid ounce of instant coffee, 12 mg per fluid ounce of brewed or drip coffee, and 64 mg per fluid ounce of espresso). In addition, coffee contains several bioactive substances, including polyphenols, diterpenes, and melanoidins, also with wide variability depending on the blend and the roasting and brewing methods. Adding sugar, ...


    • 1. Loftfield EFreedman NDDodd KWVogtmann EXiao QSinha Ret alCoffee drinking is widespread in the United States, but usual intake varies by key demographic and lifestyle factors. J Nutr2016;146:1762-8. [PMID: 27489008] doi:10.3945/jn.116.233940 CrossrefMedlineGoogle Scholar
    • 2. Wikoff DWelsh BTHenderson RBrorby GPBritt JMyers Eet alSystematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Food Chem Toxicol2017. [PMID: 28438661] doi:10.1016/j.fct.2017.04.002 CrossrefMedlineGoogle Scholar
    • 3. Crippa ADiscacciati ALarsson SCWolk AOrsini NCoffee consumption and mortality from all causes, cardiovascular disease, and cancer: a dose-response meta-analysis. Am J Epidemiol2014;180:763-75. [PMID: 25156996] doi:10.1093/aje/kwu194 CrossrefMedlineGoogle Scholar
    • 4. Gunter MJMurphy NCross AJDossus LDartois LFagherazzi Get alCoffee drinking and mortality in 10 European countries. A multinational cohort study. Ann Intern Med2017;167:236-47. doi:10.7326/M16-2945 LinkGoogle Scholar
    • 5. Park SYFreedman NDHaiman CALeMarchand LWilkens LRSetiawan VWAssociation of coffee consumption with total and cause-specific mortality among nonwhite populations. Ann Intern Med2017;167:228-35. doi:10.7326/M16-2472 LinkGoogle Scholar
    • 6. Localio ARStack CBGriswold MESensitivity analysis for unmeasured confounding: E-values for observational studies. Ann Intern Med2017;167:285-6. doi:10.7326/M17-1485 LinkGoogle Scholar
    • 7. Nordestgaard ATThomsen MNordestgaard BGCoffee intake and risk of obesity, metabolic syndrome and type 2 diabetes: a Mendelian randomization study. Int J Epidemiol2015;44:551-65. [PMID: 26002927] doi:10.1093/ije/dyv083 CrossrefMedlineGoogle Scholar
    • 8. Kwok MKLeung GMSchooling CMHabitual coffee consumption and risk of type 2 diabetes, ischemic heart disease, depression and Alzheimer's disease: a Mendelian randomization study. Sci Rep2016;6:36500. [PMID: 27845333] doi:10.1038/srep36500 CrossrefMedlineGoogle Scholar
    • 9. Nordestgaard ATNordestgaard BGCoffee intake, cardiovascular disease and all-cause mortality: observational and Mendelian randomization analyses in 95 000–223 000 individuals. Int J Epidemiol2016;45:1938-1952. [PMID: 28031317] doi:10.1093/ije/dyw325 CrossrefMedlineGoogle Scholar
    • 10. U.S. Department of Health and Human Services, U.S. Department of Agriculture. 2015–2020 Dietary Guidelines for Americans. Eighth edition. December 2015. Accessed at http://health.gov/dietaryguidelines/2015/guidelines on 19 June 2017. Google Scholar