Reviews7 April 2015
An Updated Systematic Review
    Author, Article and Disclosure Information

    This article has been corrected. The original version (PDF) is appended to this article as a Supplement.

    Background:

    Commercial and proprietary weight-loss programs are popular obesity treatment options, but their efficacy is unclear.

    Purpose:

    To compare weight loss, adherence, and harms of commercial or proprietary weight-loss programs versus control/education (no intervention, printed materials only, health education curriculum, or <3 sessions with a provider) or behavioral counseling among overweight and obese adults.

    Data Sources:

    MEDLINE and the Cochrane Database of Systematic Reviews from inception to November 2014; references identified by program staff.

    Study Selection:

    Randomized, controlled trials (RCTs) of at least 12 weeks' duration; prospective case series of at least 12 months' duration (harms only).

    Data Extraction:

    Two reviewers extracted information on study design, population characteristics, interventions, and mean percentage of weight change and assessed risk of bias.

    Data Synthesis:

    We included 45 studies, 39 of which were RCTs. At 12 months, Weight Watchers participants achieved at least 2.6% greater weight loss than those assigned to control/education. Jenny Craig resulted in at least 4.9% greater weight loss at 12 months than control/education and counseling. Nutrisystem resulted in at least 3.8% greater weight loss at 3 months than control/education and counseling. Very-low-calorie programs (Health Management Resources, Medifast, and OPTIFAST) resulted in at least 4.0% greater short-term weight loss than counseling, but some attenuation of effect occurred beyond 6 months when reported. Atkins resulted in 0.1% to 2.9% greater weight loss at 12 months than counseling. Results for SlimFast were mixed. We found limited evidence to evaluate adherence or harms for all programs and weight outcomes for other commercial programs.

    Limitation:

    Many trials were short (<12 months), had high attrition, and lacked blinding.

    Conclusion:

    Clinicians could consider referring overweight or obese patients to Weight Watchers or Jenny Craig. Other popular programs, such as Nutrisystem, show promising weight-loss results; however, additional studies evaluating long-term outcomes are needed.

    Primary Funding Source:

    None. (PROSPERO: CRD4201-4007155)

    References

    • 1. Ogden CL Carroll MD Kit BK Flegal KM Prevalence of childhood and adult obesity in the United States, 2011–2012. JAMA2014;311:806-14. [PMID: 24570244] doi:10.1001/jama.2014.732 CrossrefMedlineGoogle Scholar
    • 2. Flegal KM Graubard BI Williamson DF Gail MH Cause-specific excess deaths associated with underweight, overweight, and obesity. JAMA2007;298:2028-37. [PMID: 17986696] CrossrefMedlineGoogle Scholar
    • 3. Appel LJ Champagne CM Harsha DW Cooper LS Obarzanek E Elmer PJ et alWriting Group of the PREMIER Collaborative Research GroupEffects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial. JAMA2003;289:2083-93. [PMID: 12709466] MedlineGoogle Scholar
    • 4. Knowler WC Fowler SE Hamman RF Christophi CA Hoffman HJ Brenneman AT et alDiabetes Prevention Program Research Group10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet2009;374:1677-86. [PMID: 19878986] doi:10.1016/S0140-6736(09)61457-4 CrossrefMedlineGoogle Scholar
    • 5. Saad L. To lose weight, Americans rely more on dieting than exercise. Gallup Poll Social Series: Health and Healthcare; 2011. Accessed at www.gallup.com/poll/150986/Lose-Weight-Americans-Rely-Dieting-Exercise.aspx on 27 September 2014. Google Scholar
    • 6. IBISWorld. Weight loss services in the U.S. industry market research report; June 2014. Los Angeles: IBISWorld; 2014. Accessed at http://clients1.ibisworld.com/reports/us/industry/default.aspx?entid=1719 on 25 August 2014. Google Scholar
    • 7. Congressional Budget Office. Updated estimates of the insurance coverage provisions of the Affordable Care Act. February 2014. Accessed at www.cbo.gov/sites/default/files/cbofiles/attachments/45010-breakout-AppendixB.pdf on 17 December 2014. Google Scholar
    • 8. Sebelius K; U.S. Department of Health and Human Services. Report to Congress on preventive services and obesity-related services available to Medicaid enrollees. 2014. Accessed at www.medicaid.gov/medicaid-chip-program-information/by-topics/quality-of-care/downloads/rtc-preventive-obesity-related-services2014.pdf on 6 December 2014. Google Scholar
    • 9. Lee JS Sheer JL Lopez N Rosenbaum S Coverage of obesity treatment: a state-by-state analysis of Medicaid and state insurance laws. Public Health Rep2010;125:596-604. [PMID: 20597460] CrossrefMedlineGoogle Scholar
    • 10. Kaiser Commission on Medicaid and the Uninsured. Coverage of Preventive Services for Adults in Medicaid. Washington, DC: Henry J. Kaiser Family Foundation; 2012. Accessed at http://kaiserfamilyfoundation.files.wordpress.com/2013/01/8359.pdf on 6 December 2014. Google Scholar
    • 11. U.S. Preventive Services Task Force. Obesity in Adults: Screening and Management. Rockville, MD: U.S. Preventive Services Task Force; 2012. Accessed at www.uspreventiveservicestaskforce.org/uspstf/uspsobes.htm on 6 December 2014. Google Scholar
    • 12. Mitchell NS Ellison MC Hill JO Tsai AG Evaluation of the effectiveness of making Weight Watchers available to Tennessee Medicaid (TennCare) recipients. J Gen Intern Med2013;28:12-7. [PMID: 22618582] doi:10.1007/s11606-012-2083-8 CrossrefMedlineGoogle Scholar
    • 13. Bleich SN Herring BJ Medicaid coverage for weight loss counseling may make ‘cents' [Editorial]. J Gen Intern Med2013;28:3-5. [PMID: 22956417] doi:10.1007/s11606-012-2201-7 CrossrefMedlineGoogle Scholar
    • 14. Tsai AG Wadden TA Systematic review: an evaluation of major commercial weight loss programs in the United States. Ann Intern Med2005;142:56-66. [PMID: 15630109] doi:10.7326/0003-4819-142-1-200501040-00012 LinkGoogle Scholar
    • 15. Jensen MD Ryan DH Apovian CM Ard JD Comuzzie AG Donato KA et alAmerican College of Cardiology/American Heart Association Task Force on Practice Guidelines2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. Circulation2014;129:S102-38. [PMID: 24222017] doi:10.1161/01.cir.0000437739.71477.ee CrossrefMedlineGoogle Scholar
    • 16. Tsertsvadze A Maglione M Chou R Garritty C Coleman C Lux L et alUpdating Comparative Effectiveness Reviews: Current Efforts in AHRQ's Effective Health Care Program. Methods Guide for Comparative Effectiveness Reviews. AHRQ publication no. 11-EHC057-EF. Rockville, MD: Agency for Healthcare Research and Quality; 2011. Google Scholar
    • 17. Higgins JPT, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0. The Cochrane Collaboration; 2011. Accessed at www.cochrane-handbook.org on 1 October 2013. Google Scholar
    • 18. Heshka S Greenway F Anderson JW Atkinson RL Hill JO Phinney SD et alSelf-help weight loss versus a structured commercial program after 26 weeks: a randomized controlled study. Am J Med2000;109:282-7. [PMID: 10996578] CrossrefMedlineGoogle Scholar
    • 19. Heshka S Anderson JW Atkinson RL Greenway FL Hill JO Phinney SD et alWeight loss with self-help compared with a structured commercial program: a randomized trial. JAMA2003;289:1792-8. [PMID: 12684357] CrossrefMedlineGoogle Scholar
    • 20. Johnston CA Rost S Miller-Kovach K Moreno JP Foreyt JP A randomized controlled trial of a community-based behavioral counseling program. Am J Med2013;126:1143. [PMID: 24135513] doi:10.1016/j.amjmed.2013.04.025 CrossrefMedlineGoogle Scholar
    • 21. Jolly K Daley A Adab P Lewis A Denley J Beach J et alA randomised controlled trial to compare a range of commercial or primary care led weight reduction programmes with a minimal intervention control for weight loss in obesity: the Lighten Up trial. BMC Public Health2010;10:439. [PMID: 20663185] doi:10.1186/1471-2458-10-439 CrossrefMedlineGoogle Scholar
    • 22. Jolly K Lewis A Beach J Denley J Adab P Deeks JJ et alComparison of range of commercial or primary care led weight reduction programmes with minimal intervention control for weight loss in obesity: Lighten Up randomised controlled trial. BMJ2011;343:d6500. [PMID: 22053315] doi:10.1136/bmj.d6500 CrossrefMedlineGoogle Scholar
    • 23. Rippe JM Price JM Hess SA Kline G DeMers KA Damitz S et alImproved psychological well-being, quality of life, and health practices in moderately overweight women participating in a 12-week structured weight loss program. Obes Res1998;6:208-18. [PMID: 9618125] CrossrefMedlineGoogle Scholar
    • 24. Truby H Baic S deLooy A Fox KR Livingstone MB Logan CM et alRandomised controlled trial of four commercial weight loss programmes in the UK: initial findings from the BBC “Diet Trials”. BMJ2006;332:1309-14. [PMID: 16720619] CrossrefMedlineGoogle Scholar
    • 25. Morgan LM Griffin BA Millward DJ DeLooy A Fox KR Baic S et alComparison of the effects of four commercially available weight-loss programmes on lipid-based cardiovascular risk factors. Public Health Nutr2009;12:799-807. [PMID: 18647427] doi:10.1017/S1368980008003236 CrossrefMedlineGoogle Scholar
    • 26. Jebb SA Ahern AL Olson AD Aston LM Holzapfel C Stoll J et alPrimary care referral to a commercial provider for weight loss treatment versus standard care: a randomised controlled trial. Lancet2011;378:1485-92. [PMID: 21906798] doi:10.1016/S0140-6736(11)61344-5 CrossrefMedlineGoogle Scholar
    • 27. Walker CG Holzapfel C Loos RJ Mander AP Klopp N Illig T et alGenetic predisposition to an adverse lipid profile limits the improvement in total cholesterol in response to weight loss. Obesity (Silver Spring)2013;21:2589-95. [PMID: 23418103] doi:10.1002/oby.20328 CrossrefMedlineGoogle Scholar
    • 28. Rock CL Pakiz B Flatt SW Quintana EL Randomized trial of a multifaceted commercial weight loss program. Obesity (Silver Spring)2007;15:939-49. [PMID: 17426329] CrossrefMedlineGoogle Scholar
    • 29. Foster GD Borradaile KE VanderVeur SS LehShantz K Dilks RJ Goldbacher EM et alThe effects of a commercially available weight loss program among obese patients with type 2 diabetes: a randomized study. Postgrad Med2009;121:113-8. [PMID: 19820280] doi:10.3810/pgm.2009.09.2046 CrossrefMedlineGoogle Scholar
    • 30. Pinto AM Fava JL Hoffmann DA Wing RR Combining behavioral weight loss treatment and a commercial program: a randomized clinical trial. Obesity (Silver Spring)2013;21:673-80. [PMID: 23404824] doi:10.1002/oby.20044 CrossrefMedlineGoogle Scholar
    • 31. Rock CL Flatt SW Sherwood NE Karanja N Pakiz B Thomson CA Effect of a free prepared meal and incentivized weight loss program on weight loss and weight loss maintenance in obese and overweight women: a randomized controlled trial. JAMA2010;304:1803-10. [PMID: 20935338] doi:10.1001/jama.2010.1503 CrossrefMedlineGoogle Scholar
    • 32. Dow CA Thomson CA Flatt SW Sherwood NE Pakiz B Rock CL Predictors of improvement in cardiometabolic risk factors with weight loss in women. J Am Heart Assoc2013;2:e000152. doi:10.1161/JAHA.113.000152 CrossrefMedlineGoogle Scholar
    • 33. Rock CL Flatt SW Pakiz B Taylor KS Leone AF Brelje K et alWeight loss, glycemic control, and cardiovascular disease risk factors in response to differential diet composition in a weight loss program in type 2 diabetes: a randomized controlled trial. Diabetes Care2014;37:1573-80. [PMID: 24760261] doi:10.2337/dc13-2900 CrossrefMedlineGoogle Scholar
    • 34. Figueroa A Vicil F Sanchez-Gonzalez MA Wong A Ormsbee MJ Hooshmand S et alEffects of diet and/or low-intensity resistance exercise training on arterial stiffness, adiposity, and lean mass in obese postmenopausal women. Am J Hypertens2013;26:416-23. [PMID: 23382493] doi:10.1093/ajh/hps050 CrossrefMedlineGoogle Scholar
    • 35. Foster GD Wadden TA Lagrotte CA VanderVeur SS Hesson LA Homko CJ et alA randomized comparison of a commercially available portion-controlled weight-loss intervention with a diabetes self-management education program. Nutr Diabetes2013;3:e63. [PMID: 23507967] doi:10.1038/nutd.2013.3 CrossrefMedlineGoogle Scholar
    • 36. Dansinger ML Gleason JA Griffith JL Selker HP Schaefer EJ Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial. JAMA2005;293:43-53. [PMID: 15632335] CrossrefMedlineGoogle Scholar
    • 37. Donnelly JE Smith BK Dunn L Mayo MM Jacobsen DJ Stewart EE et alComparison of a phone vs clinic approach to achieve 10% weight loss. Int J Obes (Lond)2007;31:1270-6. [PMID: 17325684] CrossrefMedlineGoogle Scholar
    • 38. Perna F Bryner R Donley D Kolar M Hornsby G Sauers J et alEffect of diet and exercise on quality of life and fitness parameters among obese individuals. J Exerc Physiol Online1999;2:2. Google Scholar
    • 39. Smith BK VanWalleghen EL Cook-Wiens G Martin RN Curry CR Sullivan DK et alComparison of two self-directed weight loss interventions: limited weekly support vs. no outside support. Obes Res Clin Pract2009;3:I-. [PMID: 24345585] doi:10.1016/j.orcp.2009.04.001 CrossrefMedlineGoogle Scholar
    • 40. Anderson JW Reynolds LR Bush HM Rinsky JL Washnock C Effect of a behavioral/nutritional intervention program on weight loss in obese adults: a randomized controlled trial. Postgrad Med2011;123:205-13. [PMID: 21904103] doi:10.3810/pgm.2011.09.2476 CrossrefMedlineGoogle Scholar
    • 41. Davis LM Coleman C Kiel J Rampolla J Hutchisen T Ford L et alEfficacy of a meal replacement diet plan compared to a food-based diet plan after a period of weight loss and weight maintenance: a randomized controlled trial. Nutr J2010;9:11. [PMID: 20222968] doi:10.1186/1475-2891-9-11 CrossrefMedlineGoogle Scholar
    • 42. Wing RR Blair E Marcus M Epstein LH Harvey J Year-long weight loss treatment for obese patients with type II diabetes: does including an intermittent very-low-calorie diet improve outcome? Am J Med1994;97:354-62. [PMID: 7942937] CrossrefMedlineGoogle Scholar
    • 43. Doherty JU Wadden TA Zuk L Letizia KA Foster GD Day SC Long-term evaluation of cardiac function in obese patients treated with a very-low-calorie diet: a controlled clinical study of patients without underlying cardiac disease. Am J Clin Nutr1991;53:854-8. [PMID: 2008863] CrossrefMedlineGoogle Scholar
    • 44. Wadden TA Considine RV Foster GD Anderson DA Sarwer DB Caro JS Short- and long-term changes in serum leptin dieting obese women: effects of caloric restriction and weight loss. J Clin Endocrinol Metab1998;83:214-8. [PMID: 9435444] MedlineGoogle Scholar
    • 45. Wadden TA Foster GD Sarwer DB Anderson DA Gladis M Sanderson RS et alDieting and the development of eating disorders in obese women: results of a randomized controlled trial. Am J Clin Nutr2004;80:560-8. [PMID: 15321793] CrossrefMedlineGoogle Scholar
    • 46. Anderson JW Hamilton CC Crown-Weber E Riddlemoser M Gustafson NJ Safety and effectiveness of a multidisciplinary very-low-calorie diet program for selected obese individuals. J Am Diet Assoc1991;91:1582-4. [PMID: 1960353] CrossrefMedlineGoogle Scholar
    • 47. Anderson JW Brinkman-Kaplan V Hamilton CC Logan JE Collins RW Gustafson NJ Food-containing hypocaloric diets are as effective as liquid-supplement diets for obese individuals with NIDDM. Diabetes Care1994;17:602-4. [PMID: 8082533] CrossrefMedlineGoogle Scholar
    • 48. Kirschner MA Schneider G Ertel N Cortes G Supplemented starvation: a successful method for control of major obesity. J Med Soc N J1979;76:175-9. [PMID: 286061] MedlineGoogle Scholar
    • 49. Bischoff SC Damms-Machado A Betz C Herpertz S Legenbauer T Löw T et alMulticenter evaluation of an interdisciplinary 52-week weight loss program for obesity with regard to body weight, comorbidities and quality of life—a prospective study. Int J Obes (Lond)2012;36:614-24. [PMID: 21673653] doi:10.1038/ijo.2011.107 CrossrefMedlineGoogle Scholar
    • 50. Wadden TA Foster GD Letizia KA Stunkard AJ A multicenter evaluation of a proprietary weight reduction program for the treatment of marked obesity. Arch Intern Med1992;152:961-6. [PMID: 1580722] CrossrefMedlineGoogle Scholar
    • 51. Collins CE Morgan PJ Jones P Fletcher K Martin J Aguiar EJ et alEvaluation of a commercial web-based weight loss and weight loss maintenance program in overweight and obese adults: a randomized controlled trial. BMC Public Health2010;10:669. [PMID: 21047432] doi:10.1186/1471-2458-10-669 CrossrefMedlineGoogle Scholar
    • 52. Collins CE Morgan PJ Jones P Fletcher K Martin J Aguiar EJ et alA 12-week commercial web-based weight-loss program for overweight and obese adults: randomized controlled trial comparing basic versus enhanced features. J Med Internet Res2012;14:e57. [PMID: 22555246] doi:10.2196/jmir.1980 CrossrefMedlineGoogle Scholar
    • 53. Hutchesson MJ Collins CE Morgan PJ Watson JF Guest M Callister R Changes to dietary intake during a 12-week commercial web-based weight loss program: a randomized controlled trial. Eur J Clin Nutr2014;68:64-70. [PMID: 24129359] doi:10.1038/ejcn.2013.194 CrossrefMedlineGoogle Scholar
    • 54. Ditschuneit HH Flechtner-Mors M Johnson TD Adler G Metabolic and weight-loss effects of a long-term dietary intervention in obese patients. Am J Clin Nutr1999;69:198-204. [PMID: 9989680] CrossrefMedlineGoogle Scholar
    • 55. Flechtner-Mors M Ditschuneit HH Johnson TD Suchard MA Adler G Metabolic and weight loss effects of long-term dietary intervention in obese patients: four-year results. Obes Res2000;8:399-402. [PMID: 10968732] CrossrefMedlineGoogle Scholar
    • 56. Ditschuneit HH Flechtner-Mors M Value of structured meals for weight management: risk factors and long-term weight maintenance. Obes Res2001;9 Suppl 4:284S-289S. [PMID: 11707555] CrossrefMedlineGoogle Scholar
    • 57. Ditschuneit HH Frier HI Flechtner-Mors M Lipoprotein responses to weight loss and weight maintenance in high-risk obese subjects. Eur J Clin Nutr2002;56:264-70. [PMID: 11960302] CrossrefMedlineGoogle Scholar
    • 58. Noakes M Foster PR Keogh JB Clifton PM Meal replacements are as effective as structured weight-loss diets for treating obesity in adults with features of metabolic syndrome. J Nutr2004;134:1894-9. [PMID: 15284372] CrossrefMedlineGoogle Scholar
    • 59. Clifton PM Keogh JB Foster PR Noakes M Effect of weight loss on inflammatory and endothelial markers and FMD using two low-fat diets. Int J Obes (Lond)2005;29:1445-51. [PMID: 16172619] CrossrefMedlineGoogle Scholar
    • 60. Miller GD Nicklas BJ Davis C Loeser RF Lenchik L Messier SP Intensive weight loss program improves physical function in older obese adults with knee osteoarthritis. Obesity (Silver Spring)2006;14:1219-30. [PMID: 16899803] CrossrefMedlineGoogle Scholar
    • 61. Miller GD Improved nutrient intake in older obese adults undergoing a structured diet and exercise intentional weight loss program. J Nutr Health Aging2010;14:461-6. [PMID: 20617289] CrossrefMedlineGoogle Scholar
    • 62. Davis NJ Tomuta N Schechter C Isasi CR Segal-Isaacson CJ Stein D et alComparative study of the effects of a 1-year dietary intervention of a low-carbohydrate diet versus a low-fat diet on weight and glycemic control in type 2 diabetes. Diabetes Care2009;32:1147-52. [PMID: 19366978] doi:10.2337/dc08-2108 CrossrefMedlineGoogle Scholar
    • 63. Foster GD Wyatt HR Hill JO McGuckin BG Brill C Mohammed BS et alA randomized trial of a low-carbohydrate diet for obesity. N Engl J Med2003;348:2082-90. [PMID: 12761365] CrossrefMedlineGoogle Scholar
    • 64. Foster GD Wyatt HR Hill JO Makris AP Rosenbaum DL Brill C et alWeight and metabolic outcomes after 2 years on a low-carbohydrate versus low-fat diet: a randomized trial. Ann Intern Med2010;153:147-57. [PMID: 20679559] doi:10.7326/0003-4819-153-3-201008030-00005 LinkGoogle Scholar
    • 65. Friedman AN Ogden LG Foster GD Klein S Stein R Miller B et alComparative effects of low-carbohydrate high-protein versus low-fat diets on the kidney. Clin J Am Soc Nephrol2012;7:1103-11. [PMID: 22653255] doi:10.2215/CJN.11741111 CrossrefMedlineGoogle Scholar
    • 66. McAuley KA Hopkins CM Smith KJ McLay RT Williams SM Taylor RW et alComparison of high-fat and high-protein diets with a high-carbohydrate diet in insulin-resistant obese women. Diabetologia2005;48:8-16. [PMID: 15616799] CrossrefMedlineGoogle Scholar
    • 67. Yancy WS Jr Olsen MK Guyton JR Bakst RP Westman EC A low-carbohydrate, ketogenic diet versus a low-fat diet to treat obesity and hyperlipidemia: a randomized, controlled trial. Ann Intern Med2004;140:769-77. [PMID: 15148063] doi:10.7326/0003-4819-140-10-200405180-00006 LinkGoogle Scholar
    • 68. Westman EC Yancy WS Jr Olsen MK Dudley T Guyton JR Effect of a low-carbohydrate, ketogenic diet program compared to a low-fat diet on fasting lipoprotein subclasses. Int J Cardiol2006;110:212-6. [PMID: 16297472] CrossrefMedlineGoogle Scholar
    • 69. Yancy WS Jr Almirall D Maciejewski ML Kolotkin RL McDuffie JR Westman EC Effects of two weight-loss diets on health-related quality of life. Qual Life Res2009;18:281-9. [PMID: 19212822] doi:10.1007/s11136-009-9444-8 CrossrefMedlineGoogle Scholar
    • 70. Gardner CD Kiazand A Alhassan S Kim S Stafford RS Balise RR et alComparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A TO Z Weight Loss Study: a randomized trial. JAMA2007;297:969-77. [PMID: 17341711] CrossrefMedlineGoogle Scholar
    • 71. Moore SD King AC Kiernan M Gardner CD Outcome expectations and realizations as predictors of weight regain among dieters. Eat Behav2011;12:60-3. [PMID: 21184975] doi:10.1016/j.eatbeh.2010.08.007 CrossrefMedlineGoogle Scholar
    • 72. Shai I Schwarzfuchs D Henkin Y Shahar DR Witkow S Greenberg I et alDietary Intervention Randomized Controlled Trial (DIRECT) GroupWeight loss with a low-carbohydrate, Mediterranean, or low-fat diet. N Engl J Med2008;359:229-41. [PMID: 18635428] doi:10.1056/NEJMoa0708681 CrossrefMedlineGoogle Scholar
    • 73. Greenberg I Stampfer MJ Schwarzfuchs D Shai I DIRECT GroupAdherence and success in long-term weight loss diets: the Dietary Intervention Randomized Controlled Trial (DIRECT). J Am Coll Nutr2009;28:159-68. [PMID: 19828901] CrossrefMedlineGoogle Scholar
    • 74. Tirosh A Golan R Harman-Boehm I Henkin Y Schwarzfuchs D Rudich A et alRenal function following three distinct weight loss dietary strategies during 2 years of a randomized controlled trial. Diabetes Care2013;36:2225-32. [PMID: 23690533] doi:10.2337/dc12-1846 CrossrefMedlineGoogle Scholar
    • 75. Womble LG Wadden TA McGuckin BG Sargent SL Rothman RA Krauthamer-Ewing ES A randomized controlled trial of a commercial internet weight loss program. Obes Res2004;12:1011-8. [PMID: 15229342] CrossrefMedlineGoogle Scholar
    • 76. Allen JK Stephens J Dennison Himmelfarb CR Stewart KJ Hauck S Randomized controlled pilot study testing use of smartphone technology for obesity treatment. J Obes2013;2013:151597. [PMID: 24392223] doi:10.1155/2013/151597 CrossrefMedlineGoogle Scholar
    • 77. Ahrens RA Hower M Best AM Effects of weight reduction interventions by community pharmacists. J Am Pharm Assoc (2003)2003;43:583-9. [PMID: 14626750] CrossrefMedlineGoogle Scholar
    • 78. Li Z Hong K Saltsman P DeShields S Bellman M Thames G et alLong-term efficacy of soy-based meal replacements vs an individualized diet plan in obese type II DM patients: relative effects on weight loss, metabolic parameters, and C-reactive protein. Eur J Clin Nutr2005;59:411-8. [PMID: 15674301] CrossrefMedlineGoogle Scholar
    • 79. Yip I Go VL DeShields S Saltsman P Bellman M Thames G et alLiquid meal replacements and glycemic control in obese type 2 diabetes patients. Obes Res2001;9 Suppl 4:341S-347S. [PMID: 11707563] CrossrefMedlineGoogle Scholar
    • 80. Ashley JM Herzog H Clodfelter S Bovee V Schrage J Pritsos C Nutrient adequacy during weight loss interventions: a randomized study in women comparing the dietary intake in a meal replacement group with a traditional food group. Nutr J2007;6:12. [PMID: 17592648] CrossrefMedlineGoogle Scholar
    • 81. Johnston BC Kanters S Bandayrel K Wu P Naji F Siemieniuk RA et alComparison of weight loss among named diet programs in overweight and obese adults: a meta-analysis. JAMA2014;312:923-33. [PMID: 25182101] doi:10.1001/jama.2014.10397 CrossrefMedlineGoogle Scholar
    • 82. Finkelstein EA Kruger E Meta- and cost-effectiveness analysis of commercial weight loss strategies. Obesity (Silver Spring)2014;22:1942-51. [PMID: 24962106] doi:10.1002/oby.20824 CrossrefMedlineGoogle Scholar
    • 83. Johansson K Sundström J Marcus C Hemmingsson E Neovius M Risk of symptomatic gallstones and cholecystectomy after a very-low-calorie diet or low-calorie diet in a commercial weight loss program: 1-year matched cohort study. Int J Obes (Lond)2014;38:279-84. [PMID: 23736359] doi:10.1038/ijo.2013.83 CrossrefMedlineGoogle Scholar
    • 84. Madigan CD Daley AJ Lewis AL Jolly K Aveyard P Which weight-loss programmes are as effective as Weight Watchers®?: non-inferiority analysis. Br J Gen Pract2014;64:e128-36. [PMID: 24567651] doi:10.3399/bjgp14X677491 CrossrefMedlineGoogle Scholar
    • 85. Finley CE Barlow CE Greenway FL Rock CL Rolls BJ Blair SN Retention rates and weight loss in a commercial weight loss program. Int J Obes (Lond)2007;31:292-8. [PMID: 16755283] CrossrefMedlineGoogle Scholar