We agree that the results of our analysis do not provide evidence for a causal relationship between coffee drinking and reduced risk for all-cause and cause-specific mortality. We unfortunately cannot control hyperbole generated by the lay press, although we made every effort to stress the limitations of observational analyses in our interactions with journalists. As suggested, a clinical trial could provide more definitive evidence on whether coffee drinking directly affects health, and we welcome such an initiative.
Dr. Cainzos-Achirica and colleagues and Drs. Kivimaki and Ferrie suggest that residual confounding by SES may have contributed to the observed ...
Gallo V, Mackenbach JP, Ezzati M, Menvielle G, Kunst AE, Rohrmann S, et al. Social inequalities and mortality in Europe—results from a large multi-national cohort. PLoS One. 2012;7:e39013. [PMID: 22848347] doi:10.1371/journal.pone.0039013 CrossrefMedlineGoogle Scholar
Freedman ND, Park Y, Abnet CC, Hollenbeck AR, Sinha R. Association of coffee drinking with total and cause-specific mortality. N Engl J Med. 2012;366:1891-904. [PMID: 22591295] doi:10.1056/NEJMoa1112010 CrossrefMedlineGoogle Scholar
Ding M, Satija A, Bhupathiraju SN, Hu Y, Sun Q, Han J, et al. Association of coffee consumption with total and cause-specific mortality in 3 large prospective cohorts. Circulation. 2015;132:2305-15. [PMID: 26572796] doi:10.1161/CIRCULATIONAHA.115.017341 CrossrefMedlineGoogle Scholar
Park SY, Freedman ND, Haiman CA, Le Marchand L, Wilkens LR, Setiawan VW. Association of coffee consumption with total and cause-specific mortality among nonwhite populations. Ann Intern Med. 2017;167:228-35. [PMID: 28693036]. doi:10.7326/M16-2472 LinkGoogle Scholar
Saito E, Inoue M, Sawada N, Shimazu T, Yamaji T, Iwasaki M, et al. Association of coffee intake with total and cause-specific mortality in a Japanese population: the Japan Public Health Center-based Prospective Study. Am J Clin Nutr. 2015;101:1029-37. [PMID: 25762807] doi:10.3945/ajcn.114.104273 CrossrefMedlineGoogle Scholar
Author, Article, and Disclosure Information
Marc J. Gunter,
International Agency for Research on Cancer, Lyon, France (M.J.G., N.M.)
Imperial College London, London, United Kingdom (D.C.M., E.R.)
Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M16-2945.