Background: Between 2012 and 2016, a total of 14 persons in Massachusetts with a history of substance use developed an unusual amnestic syndrome that included acute, complete, and bilateral hippocampal lesions on magnetic resonance imaging (1).
Objective: To describe an additional patient whose characteristics may extend our understanding of this syndrome.
Case Report: In May 2017, a 30-year-old man was transferred from a local hospital in his native Maryland to a tertiary medical center in West Virginia for persistent memory impairment. According to family members, the patient had a history of heroin use, was recently discharged from a residential addiction ...
References
- 1.
Barash JA ,Somerville N ,DeMaria A . Cluster of an unusual amnestic syndrome—Massachusetts, 2012-2016. MMWR Morb Mortal Wkly Rep. 2017;66:76-9. [PMID: 28125568] doi:10.15585/mmwr.mm6603a2 CrossrefMedlineGoogle Scholar - 2.
Haut MW ,Hogg JP ,Marshalek PJ ,Suter BC ,Miller LE . Amnesia associated with bilateral hippocampal and bilateral basal ganglia lesions in anoxia with stimulant use. Front Neurol. 2017;8:27. [PMID: 28228745] doi:10.3389/fneur.2017.00027 CrossrefMedlineGoogle Scholar - 3. Massachusetts Department of Public Health. Data brief: an assessment of opioid-related deaths in Massachusetts (2013-2014). Accessed at www.mass.gov/eohhs/docs/dph/stop-addiction/chapter-55-opioid-overdose-study-data-brief-9-15-2016.pdf on 10 September 2017. Google Scholar
- 4.
Connelly KL ,Chen X ,Kwan PF . Bilateral hippocampal stroke secondary to acute cocaine intoxication. Oxf Med Case Reports. 2015;2015:215-7. [PMID: 26634127] doi:10.1093/omcr/omv016 CrossrefMedlineGoogle Scholar - 5.
Kofke WA ,Garman RH ,Stiller RL ,Rose ME ,Garman R . Opioid neurotoxicity: fentanyl dose-response effects in rats. Anesth Analg. 1996;83:1298-306. [PMID: 8942603] CrossrefMedlineGoogle Scholar
Author, Article, and Disclosure Information
Uzoma B. Duru,
West Virginia University School of Medicine, Morgantown, West Virginia (U.B.D., G.P., L.E.M., I.K.T., M.W.H.)
Soldiers' Home, Chelsea, Massachusetts (J.A.B.)
Note: The authors report no potential conflicts of interest and have received no financial, material, or other support for this project.
Acknowledgment: The authors thank Dr. Alfred DeMaria Jr. at the Massachusetts Department of Public Health for his critical review of the manuscript.
Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L17-0575.
This article was published at Annals.org on 30 January 2018.
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