Letters15 November 2016
    Author, Article, and Disclosure Information


    Dr. Hughes and Mr. Klemperer and Dr. Schuurmans rightly point to the limits of the generalizability of our study's findings. When designing a randomized, controlled trial, selecting a particular intervention and choosing what to compare it with is always difficult. Smoking reduction is a complex issue—many possible ways and scenarios to achieve reduction are available, which may result in varying success rates. This strategy is in contrast to abrupt quitting, which allows for less opportunity for variation. Therefore, the general question of whether trying to reduce consumption ahead of a target quit date is counterproductive may have no ...


    • 1. Cheong YYong HHBorland RDoes how you quit affect success? A comparison between abrupt and gradual methods using data from the International Tobacco Control Policy Evaluation Study. Nicotine Tob Res2007;9:801-10. [PMID: 17654293] CrossrefMedlineGoogle Scholar
    • 2. Ebbert JOHughes JRWest RJRennard SIRuss CMcRae TDet alEffect of varenicline on smoking cessation through smoking reduction: a randomized clinical trial. JAMA2015;313:687-94. [PMID: 25688780] doi:10.1001/jama.2015.280 CrossrefMedlineGoogle Scholar
    • 3. Lindson-Hawley NShinkins BWest RMichie SAveyard PDoes cigarette reduction while using nicotine replacement therapy prior to a quit attempt predict abstinence following quit date? Addiction2016;111:1275-82. [PMID: 26990374] doi:10.1111/add.13330 CrossrefMedlineGoogle Scholar