Letters
15 September 2015

Decrease in Surgery for Clostridium difficile Infection After Starting a Program to Transplant Fecal Microbiota

Publication: Annals of Internal Medicine
Volume 163, Number 6
Background: Clostridium difficile infection is increasing in incidence, severity, and mortality (1). Surgery is sometimes used to manage complicated infections because it improves short-term survival (2); however, it is associated with high rates of morbidity and poor long-term survival (3). Surgery is most often used when disease recurs and cannot be controlled with antibiotics, because the risk for severe complications and mortality increases greatly during these recurrences (4). An alternative effective treatment for recurrent disease involves delivery of stool from a healthy donor directly into a patient's colon. This procedure is known as fecal microbiota transplantation …

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References

1.
Lessa FCMu YBamberg WMBeldavs ZGDumyati GKDunn JRet al. Burden of Clostridium difficile infection in the United States. N Engl J Med. 2015;372:825-34. [PMID: 25714160]  doi: 10.1056/NEJMoa1408913
2.
Stewart DBHollenbeak CSWilson MZ. Is colectomy for fulminant Clostridium difficile colitis life saving? A systematic review. Colorectal Dis. 2013;15:798-804. [PMID: 23350898]  doi: 10.1111/codi.12134
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Dallas KBCondren ADivino CM. Life after colectomy for fulminant Clostridium difficile colitis: a 7-year follow up study. Am J Surg. 2014;207:533-9. [PMID: 24674828]  doi: 10.1016/j.amjsurg.2013.04.008
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Olsen MAYan YReske KAZilberberg MDDubberke ER. Recurrent Clostridium difficile infection is associated with increased mortality. Clin Microbiol Infect. 2015;21:164-70. [PMID: 25658560]  doi: 10.1016/j.cmi.2014.08.017
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Drekonja DReich JGezahegn SGreer NShaukat AMacDonald Ret al. Fecal microbiota transplantation for Clostridium difficile infection: a systematic review. Ann Intern Med. 2015;162:630-8. [PMID: 25938992]  doi: 10.7326/M14-2693

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Information & Authors

Information

Published In

cover image Annals of Internal Medicine
Annals of Internal Medicine
Volume 163Number 615 September 2015
Pages: 487 - 488

History

Published online: 15 September 2015
Published in issue: 15 September 2015

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Giovanni Cammarota, MD
From A. Gemelli Hospital, Catholic University, Rome, Italy.
Gianluca Ianiro, MD
From A. Gemelli Hospital, Catholic University, Rome, Italy.
Sabina Magalini, MD
From A. Gemelli Hospital, Catholic University, Rome, Italy.
Antonio Gasbarrini, MD
From A. Gemelli Hospital, Catholic University, Rome, Italy.
Daniele Gui, MD
From A. Gemelli Hospital, Catholic University, Rome, Italy.

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Giovanni Cammarota, Gianluca Ianiro, Sabina Magalini, et al. Decrease in Surgery for Clostridium difficile Infection After Starting a Program to Transplant Fecal Microbiota. Ann Intern Med.2015;163:487-488. [Epub 15 September 2015]. doi:10.7326/L15-5139

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