Therapeutics
May 1, 2006

Long-term fenofibrate therapy did not reduce major coronary events but may reduce total CVD events in type 2 diabetes mellitus

Publication: ACP Journal Club
Volume 144, Number 3

Source Citation

Keech A, Simes RJ, Barter P, et al. Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet. 2005;366:1849-61. https://pubmed.ncbi.nlm.nih.gov/16310551/

Clinical Impact Ratings

GIM/FP/GP: 6 out of 7
Cardiology: 6 out of 7
Endocrinology: 5 out of 7

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References

1.
Frick MH, Elo O, Haapa K, et al. Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease. N Engl J Med. 1987;317:1237-45. [PMID: 3313041]
2.
Rubins HB, Robins SJ, Collins D, et al. Diabetes, plasma insulin, and cardiovascular disease: subgroup analysis from the Department of Veterans Affairs high-density lipoprotein intervention trial (VA-HIT). Arch Intern Med. 2002;162:2597-604. [PMID: 12456232]
3.
Tenenbaum A, Motro M, Fisman EZ, et al. Bezafibrate for the secondary prevention of myocardial infarction in patients with metabolic syndrome. Arch Intern Med. 2005;165:1154-60. [PMID: 15911729]
4.
Gami AS, Montori VM, Erwin PJ, et al. Systematic review of lipid lowering for primary prevention of coronary heart disease in diabetes. BMJ. 2003;326:528-9. [PMID: 12623912]
5.
Action to Control Cardiovascular Risk in Diabetes. www.accordtrial.org/public/index.cfm

Information & Authors

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Published In

cover image ACP Journal Club
ACP Journal Club
Volume 144Number 3May 1, 2006
Pages: 65

History

Published in issue: May 1, 2006
Published online: 9 March 2020

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Affiliations

Matthew McQueen, MD
Hamilton Health Sciences, Hamilton, Ontario, Canada (M.M.)

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