Upper gastrointestinal event risk with COX-2 inhibitors depended on known risk factors
Source Citation
Laine L, Bombardier C, Hawkey CJ, et al. Stratifying the risk of NSAID-related upper gastrointestinal clinical events: results of a double-blind outcomes study in patients with rheumatoid arthritis. Gastroenterology. 2002;123:1006-12. https://pubmed.ncbi.nlm.nih.gov/12360461/
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References
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Ray W, Stein MC, Daugherty JR, et al. COX-2 selective non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease. Lancet. 2002;360:1071-3. [PMID: 12383990]
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Mamdani M, Rochon PA, Juurlink DN, et al. Observational study of upper gastrointestinal haemorrhage in elderly patients given selective cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs. BMJ. 2002;325:624-9. [PMID: 12242172]
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Published In
ACP Journal Club
Volume 138 • Number 2 • March 1, 2003
Pages: 51
History
Published in issue: March 1, 2003
Published online: 9 March 2020
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© 2003 American College of Physicians.
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