ACP Journal Club
2 February 2021

In inpatients with COVID-19, none of remdesivir, hydroxychloroquine, lopinavir, or interferon β-1a differed from standard care for in-hospital mortality

Publication: Annals of Internal Medicine
Volume 174, Number 2

Abstract

Source Citation

Pan H, Peto R, Henao-Restrepo AM, et al. Repurposed antiviral drugs for Covid-19—interim WHO Solidarity Trial results. N Engl J Med. 2020. [Epub ahead of print.] https://pubmed.ncbi.nlm.nih.gov/33264556/

Abstract

Clinical Impact Ratings

Hospitalists: 6 out of 7
Infectious Disease: 5 out of 7
Critical Care: 5 out of 7

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References

1.
RECOVERY Collaborative Group. Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet. 2020;396:1345-52. [PMID: 33031764]
2.
Beigel JH, Tomashek KM, Dodd LE, et al. Remdesivir for the treatment of Covid-19–final report. N Engl J Med. 2020;383:1813-26. [PMID: 32445440]
3.
Monk PD, Marsden RJ, Tear VJ, et al. Safety and efficacy of inhaled nebulized interferon β-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomized, double-blind, placebo-controlled, phase 2 trial. Lancet Respir Med. 2020. [Epub ahead of print.] [PMID: 33189161]
4.
Bastard P, Rosen LB, Zhang Q, et al. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science. 2020;370:eabd4585. [PMID: 32972996]

Information & Authors

Information

Published In

cover image Annals of Internal Medicine
Annals of Internal Medicine
Volume 174Number 2February 2021
Pages: JC17

History

Published online: 2 February 2021
Published in issue: February 2021

Keywords

Authors

Affiliations

Raina Zhang, BA
Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA (R.Z., E.M.)
Eleftherios Mylonakis, MD
Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA (R.Z., E.M.)
Disclosures: The commentators have disclosed no conflicts of interest. The forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M20-7313.
This article was published at Annals.org on 2 February 2021.

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Raina Zhang, Eleftherios Mylonakis. In inpatients with COVID-19, none of remdesivir, hydroxychloroquine, lopinavir, or interferon β-1a differed from standard care for in-hospital mortality. Ann Intern Med.2021;174:JC17. [Epub 2 February 2021]. doi:10.7326/ACPJ202102160-017

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