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ACP Journal Club
21 January 2020

In patients with recent ACS and uncontrolled dyslipidemia, alirocumab reduced MACE regardless of previous CABG

Authors: Anthony P. Carnicelli, MD, and Christopher B. Granger, MDAuthor, Article, & Disclosure Information
Publication: Annals of Internal Medicine
Volume 172, Number 2
https://doi.org/10.7326/ACPJ202001210-003
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Abstract

Source Citation

Goodman SG, Aylward PE, Szarek M, et al. Effects of alirocumab on cardiovascular events after coronary bypass surgery. J Am Coll Cardiol. 2019;74:1177-86. https://pubmed.ncbi.nlm.nih.gov/31466614/

Abstract

Clinical Impact Ratings

GIM/FP/GP: 6 out of 7
Cardiology: 6 out of 7

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References

1.
Sabatine MS. PCSK9 inhibitors: clinical evidence and implementation. Nat Rev Cardiol. 2019;16:155-65. [PMID: 30420622]
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Kulik A, Ruel M, Jneid H, et al. Secondary prevention after coronary artery bypass graft surgery: a scientific statement from the American Heart Association. Circulation. 2015;131:927-64. [PMID: 25679302]
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Information & Authors

Information

Published In

cover image Annals of Internal Medicine
Annals of Internal Medicine
Volume 172 • Number 2 • 21 January 2020
Pages: JC3

History

Published online: 21 January 2020
Published in issue: 21 January 2020

Keywords

  1. Absolute risk reduction
  2. Acute coronary syndrome
  3. Atherosclerotic cardiovascular disease
  4. Hazard ratio
  5. Heart failure
  6. Lipoproteins
  7. Low density lipoprotein cholesterol
  8. Mortality
  9. Number needed to treat
  10. Statins

Copyright

© 2020 American College of Physicians.

Authors

Affiliations

Anthony P. Carnicelli, MD
Duke University, Durham, North Carolina, USA (A.P.C., C.B.G.)
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Christopher B. Granger, MD
Duke University, Durham, North Carolina, USA (A.P.C., C.B.G.)
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Disclosures: The commentators have disclosed no conflicts of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M19-2922.
This article was published at Annals.org on 7 January 2020.

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Anthony P. Carnicelli, Christopher B. Granger. In patients with recent ACS and uncontrolled dyslipidemia, alirocumab reduced MACE regardless of previous CABG. Ann Intern Med.2020;172:JC3. [Epub 21 January 2020]. doi:10.7326/ACPJ202001210-003

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