In various articles and textbooks dealing with myxedema, very little has been said regarding the heart. The literature covering the subject of the heart in myxedema is marked by paucity, contradiction, and confusion.

In 1918 Zondek1 introduced the term "myxedema heart" and described its characteristics as follows:

I. Before treatment with thyroid.

1. Dilatation of the left and right heart which may be of a very high degree.

2. Slow, indolent heart action with normal blood pressure.

3. Lowering of the auricular wave and the T-wave of the electrocardiogram.

II. Following treatment with thyroid.

1. Return...


  • 1 ZONDEK H: Das Myxödemherz, München med. Wchnschr., 1918, lxv, 1180-1182. Google Scholar
  • 2 ZONDEK H: Das Myxödemherz, (II. Mitteilung), München med. Wchnschr., 1919, lxvi, 681-683. Google Scholar
  • 3 ASSMANN H: Das Myxödemherz, München med. Wchnschr., 1919, lxvi, 9. Google Scholar
  • 4 MEISSNER R: Zur Klinik des Myxödemherzens, München med. Wchnschr., 1920, lxvii, 1316. Google Scholar
  • 5 LAUBRYMUSSIO-FOURNIÉRWALSER CJCJ: Syndrome angineux et insuffisance thyroidïenne, Bull. et mém. Soc. méd. de hôp. de Paris, 1924, xlviii, 1592-1598. Google Scholar
  • 6 FAHR G: Myxedema heart, Jr. Am. Med. Assoc., 1925, lxxxiv, 345-349. CrossrefGoogle Scholar
  • 7 CHRISTIAN HA: The heart and its management in myxedema, Rhode Island Med. Jr., 1925, viii, 109-113. Google Scholar
  • 8 WILLIUSHAINES FASF: The status of the heart in myxedema, Am. Heart Jr., 1925, i, 67-72. CrossrefGoogle Scholar
  • 9 CASE CE: An analysis of fifty-eight cases of myxedema, Clifton Med. Bull., 1925, xi, 112. Google Scholar
  • 10 MEANSWHITEKRANTZ JHPDCI: Observations on the heart in myxedema, with special reference to dilatation and angina pectoris, Boston Med. and Surg. Jr., 1926, cxcv, 455-460. CrossrefGoogle Scholar
  • 11 THACHERWHITE CPD: The electrocardiogram in myxedema, Am. Jr. Med. Sci., 1926, clxxi, 61-66. CrossrefGoogle Scholar
  • 12 SPRAGUEWHITE HBPD: The significance of electrocardiograms of low voltage, Jr. Clin. Invest., 1926, iii, 109-121. CrossrefGoogle Scholar
  • 13 ZINSRÖSLER BH: Kasuistischer Beitrag zur Beeinflussung des Myxödemherzens durch Thyreoidin, Wien. klin. Wchnschr., 1926, xxxix, 1360-1361. Google Scholar
  • 14 SCHITTENHELMEISLER AB: Über die Wirksamkeit des Thyroxins (Schering) bei Endokrin bedingten Störungen, Klin. Wchnschr., 1927, vi, 1935-1938. CrossrefGoogle Scholar
  • 15 FAHR G: Myxedema heart, Am. Heart Jr., 1927, iii, 14-30. CrossrefGoogle Scholar
  • 16 DUDEN CW: Myxedema with cardiac decompensation and hypertension which disappeared under thyroid medication, Jr. Missouri Med. Assoc., 1929, xxvi, 25-27. Google Scholar
  • 17 HOLZMAN JE: Myxedema heart, with report of two cases, Am. Heart Jr., 1929, iv, 351-366. CrossrefGoogle Scholar
  • 18 ZISKIN T: Angina pectoris associated with myxedema heart, U. S. Vet. Bur. Med. Bull., 1930, vi, 24-26. Google Scholar
  • 19 DAVIS JC: Myxedema heart, with report of one case, ANN. INT. MED., 1931, iv, 733-741. LinkGoogle Scholar
  • 20 TUNG CL: The status of the heart in myxedema, Am. Heart Jr., 1931, vi, 734-742. CrossrefGoogle Scholar
  • 21 AYMANROSENBLUMFALCONLESSES DHM: "Myxedema Heart" without evidence of cardiac insufficiency; report of two cases, Jr. Am. Med. Assoc., 1932, xcviii, 1721-1725. CrossrefGoogle Scholar
  • 22 REIDKENWAY WDFL: Electrocardiographic signs associated with low basal metabolism, Endocrinology, 1929, xiii, 191-204. CrossrefGoogle Scholar
  • 23 NOBELROSENBLÜTHSAMET EAB: Das Elektrokardiogramm des kindlichen Myxödems, Ztschr. f. d. ges. exper. Med., 1924, xliii, 332-341. CrossrefGoogle Scholar
  • 24 MEANS JH: Hypothyroid heart disease, N. E. Jr. Med., 1933, ccviii, 541-542. CrossrefGoogle Scholar
  • 25 Trans. Clin. Soc. London, Report of a Committee of the Clinical Society of London, nominated Dec. 19, 1883, to investigate the subject of myxedema; Supplement to Vol. 21, London, 1888. Google Scholar
  • 26 GOLDBERG SA: Changes in organs of thyroidectomized sheep and goats, Quart. Jr. Exper. Physiol., 1927, xvii, 15-30. CrossrefGoogle Scholar

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