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Letters21 May 2013

Fecal Microbiota Therapy for Recurrent Clostridium difficile Infection in HIV-Infected Persons

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    https://doi.org/10.7326/0003-4819-158-10-201305210-00021
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    Background: Recurrent Clostridium difficile infection is common and difficult to manage. It returns in approximately 20% to 30% of cases after a first episode and more frequently after recurrent episodes (1). Because of the high rate of recurrence, many treatment alternatives have been proposed, especially metronidazole or vancomycin (including pulsed or tapered vancomycin); however, these therapies are often unsuccessful (1, 2). Disrupted fecal microbiota from previous antibiotics play a major role in recurrent C. difficile infection, and fecal microbiota therapy works by restoring the recipient's natural microbiota (1). The procedure includes testing the donor for infections that could be transmitted ...

    References

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