TO THE EDITOR:
Parker and colleagues (1) found no significant association between fetuin-A levels and mortality in a cohort with prevalent coronary artery disease. Our understanding of fetuin-A biology is greatly undermined by the lack of agreement among different methods of measurement. It is therefore particularly important that method descriptions are unambiguous. The authors comment that their nephelometric fetuin-A assay “uses the same high-specificity antibody as commercially available enzyme-linked immunosorbent assays.” It is unclear to which commercially available assays they are referring—the 2 most widely used commercial kits not only use different antisera but also use a sandwich format with ...
References
- 1.
Parker BD ,Schurgers LJ ,Brandenburg VM ,Christenson RH ,Vermeer C ,Ketteler M ,et al . The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: the Heart and Soul Study. Ann Intern Med. 2010;152:640-8. [PMID:20479029 ] LinkGoogle Scholar - 2.
Smith ER ,Ford ML ,Tomlinson LA ,Rocks BF ,Rajkumar C ,Holt SG . Poor agreement between commercial ELISAs for plasma fetuin-A: an effect of protein glycosylation? Clin Chim Acta. 2010;411:1367-70. [PMID:20420817 ] CrossrefMedlineGoogle Scholar - 3.
Hermans MM ,Brandenburg V ,Ketteler M ,Kooman JP ,van der Sande FM ,Boeschoten EW ,et al ;Netherlands cooperative study on the adequacy of Dialysis (NECOSAD) . Association of serum fetuin-A levels with mortality in dialysis patients. Kidney Int. 2007;72:202-7. [PMID:17342178 ] CrossrefMedlineGoogle Scholar - 4.
Ford ML ,Tomlinson LA ,Smith ER ,Rajkumar C ,Holt SG . Fetuin-A is an independent determinant of change of aortic stiffness over 1 year in non-diabetic patients with CKD stages 3 and 4. Nephrol Dial Transplant. 2010;25:1853-8. [PMID:20075438 ] CrossrefMedlineGoogle Scholar
Author, Article and Disclosure Information
From Brighton and Sussex University Hospitals NHS Trust, Brighton BN2 5BE, United Kingdom.
Disclosures: None disclosed.
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