Background: Muscle toxicity is the most important adverse effect of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins). The incidence of statin-induced myopathy is debated, depending in part on whether the milder and more common symptoms of muscle ache, weakness, and cramping are part of a continuum that also includes rhabdomyolysis, renal failure, and death. Although creatine kinase (CK) elevation is a marker of injury often used clinically to follow the severity of statin-induced myopathy, it has limited usefulness for defining statin-induced myopathy. For example, muscle-toxicity symptoms and biopsy evidence of mitochondrial dysfunction without CK elevation have been documented during statin therapy ...
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From Cleveland Clinic Foundation, Wooster, OH 44691; and Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205.
Disclosures: None disclosed.
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