Letters15 April 2008
    Author, Article, and Disclosure Information

    Background: A subset of patients with Clostridium difficile–associated diarrhea will develop fulminant, life-threatening C. difficile infection that is refractory to medical therapy. Surgical options for fulminant disease are associated with high mortality rates. We describe a patient with fulminant C. difficile infection successfully treated with donor stool by retention enema.

    Objective: To describe a successful case of using fecal bacteriotherapy to treat life-threatening, fulminant C. difficile enterocolitis.

    Case Report: A 69-year-old man was admitted to the hospital after undergoing radical prostatectomy. The patient was given perioperative, intravenous cefazolin. On postoperative day 2, the patient developed an ileus and oliguric renal ...

    References

    • 1. Dallal RMHarbrecht BGBoujoukas AJSirio CAFarkas LMLee KKet alFulminant Clostridium difficile: an underappreciated and increasing cause of death and complications. Ann Surg2002;235:363-72. [PMID: 11882758] CrossrefMedlineGoogle Scholar
    • 2. Koss KClark MASanders DSMorton DKeighley MRGoh JThe outcome of surgery in fulminant Clostridium difficile colitis. Colorectal Dis2006;8:149-54. [PMID: 16412077] CrossrefMedlineGoogle Scholar
    • 3. Aas JGessert CEBakken JSRecurrent Clostridium difficile colitis: case series involving 18 patients treated with donor stool administered via a nasogastric tube. Clin Infect Dis2003;36:580-5. [PMID: 12594638] CrossrefMedlineGoogle Scholar
    • 4. Persky SEBrandt LJTreatment of recurrent Clostridium difficile-associated diarrhea by administration of donated stool directly through a colonoscope. Am J Gastroenterol2000;95:3283-5. [PMID: 11095355] MedlineGoogle Scholar
    • 5. Tvede MRask-Madsen JBacteriotherapy for chronic relapsing Clostridium difficile diarrhoea in six patients. Lancet1989;1:1156-60. [PMID: 2566734] CrossrefMedlineGoogle Scholar