Coffee Consumption and Risk for Type 2 Diabetes Mellitus
Publication: Annals of Internal Medicine
Volume 140, Number 1
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Abstract
Background:
In small, short-term studies, acute administration of caffeine decreases insulin sensitivity and impairs glucose tolerance.
Objective:
To examine the long-term relationship between consumption of coffee and other caffeinated beverages and incidence of type 2 diabetes mellitus.
Design:
Prospective cohort study.
Setting:
The Nurses' Health Study and Health Professionals' Follow-up Study.
Participants:
The authors followed 41 934 men from 1986 to 1998 and 84 276 women from 1980 to 1998. These participants did not have diabetes, cancer, or cardiovascular disease at baseline.
Measurements:
Coffee consumption was assessed every 2 to 4 years through validated questionnaires.
Results:
The authors documented 1333 new cases of type 2 diabetes in men and 4085 new cases in women. The authors found an inverse association between coffee intake and type 2 diabetes after adjustment for age, body mass index, and other risk factors. The multivariate relative risks for diabetes according to regular coffee consumption categories (0, <1, 1 to 3, 4 to 5, or ≥ 6 cups per day) in men were 1.00, 0.98, 0.93, 0.71, and 0.46 (95% CI, 0.26 to 0.82; P = 0.007 for trend), respectively. The corresponding multivariate relative risks in women were 1.00, 1.16, 0.99, 0.70, and 0.71 (CI, 0.56 to 0.89; P < 0.001 for trend), respectively. For decaffeinated coffee, the multivariate relative risks comparing persons who drank 4 cups or more per day with nondrinkers were 0.74 (CI, 0.48 to 1.12) for men and 0.85 (CI, 0.61 to 1.17) for women. Total caffeine intake from coffee and other sources was associated with a statistically significantly lower risk for diabetes in both men and women.
Conclusions:
These data suggest that long-term coffee consumption is associated with a statistically significantly lower risk for type 2 diabetes.
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References
1.
Harris MI, Flegal KM, Cowie CC, Eberhardt MS, Goldstein DE, Little RR, et al . 1998 Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988-1994. Diabetes Care. 21:518-24. [PMID: 9571335]
2.
Hu FB, Manson JE, Stampfer MJ, Colditz G, Liu S, Solomon CG, et al . Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med. 2001;345:790-7. [PMID: 11556298]
3.
Keijzers GB, De Galan BE, Tack CJ, Smits P. Caffeine can decrease insulin sensitivity in humans. Diabetes Care. 2002;25:364-9. [PMID: 11815511]
4.
Lundsberg LS. Coffeine consumption. In: Spiller GA, eds. Caffeine. Boca Raton, FL: CRC Pr; 1998:199-224.
5.
Cheraskin E, Ringsdorf WM Jr. Blood-glucose levels after caffeine. Lancet. 1968;2:689. [PMID: 4175524]
6.
Feinberg LJ, Sandberg H, De Castro O, Bellet S. Effects of coffee ingestion on oral glucose tolerance curves in normal human subjects. Metabolism. 1968;17:916-22. [PMID: 4300352]
7.
Graham TE, Sathasivam P, Rowland M, Marko N, Greer F, Battram D. Caffeine ingestion elevates plasma insulin response in humans during an oral glucose tolerance test. Can J Physiol Pharmacol. 2001;79:559-65. [PMID: 11478588]
8.
Greer F, Hudson R, Ross R, Graham T. Caffeine ingestion decreases glucose disposal during a hyperinsulinemic-euglycemic clamp in sedentary humans. Diabetes. 2001;50:2349-54. [PMID: 11574419]
9.
Dulloo AG, Geissler CA, Horton T, Collins A, Miller DS. Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers. Am J Clin Nutr. 1989;49:44-50. [PMID: 2912010]
10.
Astrup A, Toubro S, Cannon S, Hein P, Breum L, Madsen J. Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. Am J Clin Nutr. 1990;51:759-67. [PMID: 2333832]
11.
Bracco D, Ferrarra JM, Arnaud MJ, Jequier E, Schutz Y. Effects of caffeine on energy metabolism, heart rate, and methylxanthine metabolism in lean and obese women. Am J Physiol. 1995;269:671-8. [PMID: 7485480]
12.
Robertson D, Wade D, Workman R, Woosley RL, Oates JA. Tolerance to the humoral and hemodynamic effects of caffeine in man. J Clin Invest. 1981;67:1111-7. [PMID: 7009653]
13.
van Dam RM, Feskens EJ. Coffee consumption and risk of type 2 diabetes mellitus. Lancet. 2002;360:1477-8. [PMID: 12433517]
14.
Grobbee DE, Rimm EB, Giovannucci E, Colditz G, Stampfer M, Willett W. Coffee, caffeine, and cardiovascular disease in men. N Engl J Med. 1990;323:1026-32. [PMID: 2215561]
15.
Colditz GA, Manson JE, Hankinson SE. The Nurses' Health Study: 20-year contribution to the understanding of health among women. J Womens Health. 1997;6:49-62. [PMID: 9065374]
16.
Salvini S, Hunter DJ, Sampson L, Stampfer MJ, Colditz GA, Rosner B, Willett WC. Food-based validation of a dietary questionnaire: the effects of week-to-week variation in food consumption. Int J Epidemiol. 1989;18:858-67. [PMID: 2621022]
17.
Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. National Diabetes Data Group. Diabetes. 1979;28:1039-57. [PMID: 510803]
18.
Manson JE, Colditz GA, Stampfer MJ, Willett WC, Krolewski AS, Rosner B, et al . A prospective study of maturity-onset diabetes mellitus and risk of coronary heart disease and stroke in women. Arch Intern Med. 1991;151:1141-7. [PMID: 2043016]
19.
Field AE, Coakley EH, Must A, Spadano JL, Laird N, Dietz WH, et al . Impact of overweight on the risk of developing common chronic diseases during a 10-year period. Arch Intern Med. 2001;161:1581-6. [PMID: 11434789]
20.
Cox DR, Oakes D. Analysis of Survival Data. London: Chapman and Hall; 1984.
21.
Salmeron J, Manson JE, Stampfer MJ, Colditz GA, Wing AL, Willett WC. Dietary fiber, glycemic load, and risk of non–insulin-dependent diabetes mellitus in women. JAMA. 1997;277:472-7. [PMID: 9020271]
22.
Hu FB, Stampfer MJ, Manson JE, Rimm E, Colditz GA, Rosner BA, et al . Dietary fat intake and the risk of coronary heart disease in women. N Engl J Med. 1997;337:1491-9. [PMID: 9366580]
23.
Thong FS, Graham TE. Caffeine-induced impairment of glucose tolerance is abolished by β-adrenergic receptor blockade in humans. J Appl Physiol. 2002;92:2347-52. [PMID: 12015346]
24.
Brown CR, Benowitz NL. Caffeine and cigarette smoking: behavioral, cardiovascular, and metabolic interactions. Pharmacol Biochem Behav. 1989;34:565-70. [PMID: 2623013]
25.
Spriet LL, MacLean DA, Dyck DJ, Hultman E, Cederblad G, Graham TE. Caffeine ingestion and muscle metabolism during prolonged exercise in humans. Am J Physiol. 1992;262:891-8. [PMID: 1616022]
26.
Ryu S, Choi SK, Joung SS, Suh H, Cha YS, Lee S, et al . Caffeine as a lipolytic food component increases endurance performance in rats and athletes. J Nutr Sci Vitaminol Tokyo. 2001;47:139-46. [PMID: 11508705]
27.
Ramsey JJ, Colman RJ, Swick AG, Kemnitz JW. Energy expenditure, body composition, and glucose metabolism in lean and obese rhesus monkeys treated with ephedrine and caffeine. Am J Clin Nutr. 1998;68:42-51. [PMID: 9665095]
28.
Astrup A, Breum L, Toubro S, Hein P, Quaade F. The effect and safety of an ephedrine/caffeine compound compared to ephedrine, caffeine and placebo in obese subjects on an energy restricted diet. A double blind trial. Int J Obes Relat Metab Disord. 1992;16:269-77. [PMID: 1318281]
29.
Boozer CN, Daly PA, Homel P, Solomon JL, Blanchard D, Nasser JA, et al . Herbal ephedra/caffeine for weight loss: a 6-month randomized safety and efficacy trial. Int J Obes Relat Metab Disord. 2002;26:593-604. [PMID: 12032741]
30.
Devasagayam TP, Kamat JP, Mohan H, Kesavan PC. Caffeine as an antioxidant: inhibition of lipid peroxidation induced by reactive oxygen species. Biochim Biophys Acta. 1996;1282:63-70. [PMID: 8679661]
31.
Meyer KA, Kushi LH, Jacobs DR Jr, Slavin J, Sellers TA, Folsom AR. Carbohydrates, dietary fiber, and incident type 2 diabetes in older women. Am J Clin Nutr. 2000;71:921-30. [PMID: 10731498]
Information & Authors
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Published In
Annals of Internal Medicine
Volume 140 • Number 1 • 6 January 2004
Pages: 1 - 8
History
Published online: 6 January 2004
Published in issue: 6 January 2004
Keywords
Copyright
© 2004 American College of Physicians.
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Coffee Consumption and Risk for Type 2 Diabetes Mellitus. Ann Intern Med.2004;140:1-8. [Epub 6 January 2004]. doi:10.7326/0003-4819-140-1-200401060-00005
Coffee Consumption and Risk for Type 2 Diabetes Mellitus. Ann Intern Med.2004;140:1-8. [Epub 6 January 2004]. doi:10.7326/0003-4819-140-1-200401060-00005
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