Editorials
1 March 1991

Emerging Resistance to Fluoroquinolones in Staphylococci: An Alert

Publication: Annals of Internal Medicine
Volume 114, Number 5

Excerpt

The fluoroquinolones are orally administered antimicrobial agents introduced in the mid-1980s. Although they are particularly effective for treating gram-negative bacillary infections, some agents, including ciprofloxacin, ofloxacin, and pefloxacin, are also active against gram-positive organisms. These agents have shown promise as alternatives to parenteral vancomycin for treating infections with methicillin-resistant Staphylococcus aureus. With fluoroquinolone use, however, therapeutic failures associated with isolation of fluoroquinolone-resistant strains of staphylococci are being increasingly documented. We discuss the use of fluoroquinolones as therapeutic agents for staphylococcal infections, problems with bacterial resistance, and approaches to suppression of resistance.
Staphylococci have long been important causes of both community-...

Get full access to this article

View all available purchase options and get full access to this article.

References

1.
Horan TCulver D, and Jarvis W. Pathogens causing nosocomial infections: preliminary data from the national nosocomial infections surveillance system. Antimicrobic Newsletter. 1988;5:65-7.
2.
Barry A and Jones R. In vitro activity of ciprofloxacin against gram-positive cocci. Am J Med. 1987;82(Suppl 4A):27-32.
3.
Mitsuhashi S. Comparative antibacterial activity of new quinolone-carboxylic acid derivatives. Rev Infect Dis. 1988;10(Suppl. 1):S27-31.
4.
Espinoza AChin NNovelli A, and Neu H. Comparative in vitro activity of a new fluorinated 4-quinolone, T-3262 (A-60969). Antimicrob Agents Chemother. 1988;32:663-70.
5.
Jones R and Barry A. In vitro evaluation of WIN 57273, a new broad-spectrum fluoroquinolone. Antimicrob Agents Chemother. 1990;34:306-13.
6.
Smith S and Eng R. Activity of ciprofloxacin against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 1985;27:688-91.
7.
Sande MBrooks-Fournier R, and Gerberding J. Use of animal models in evaluation of the quinolones. Rev Infect Dis. 1988;10(Suppl. 1):S113-6.
8.
Kaatz GSeo SBarriere SAlbrecht L, and Rybak M. Efficacy of ofloxacin in experimental Staphylococcus aureus endocarditis. Antimicrob Agents Chemother. 1990;34:257-60.
9.
Desplaces N and Acar J. New quinolones in the treatment of bone and joint infections. Rev Infect Dis. 1988;10(Suppl. 1):S179-83.
10.
Piercy EBarbaro DLuby J, and Mackowiak P. Ciprofloxacin for methicillin-resistant Staphylococcus aureus infections. Antimicrob Agents Chemother. 1989;33:128-30.
11.
Righter J. Ciprofloxacin treatment of Staphylococcus aureus infections. J Antimicrob Chemother. 1987;20:595-7.
12.
Humphreys H and Mulvhill E. Ciprofloxacin-resistant Staphylococcus aureus [Letter]. Lancet. 1985;2:383.
13.
French GLing JLing T, and Hui Y. Susceptibility of Hong Kong isolates of methicillin-resistant Staphylococcus aureus to antimicrobial agents. J Antimicrob Chemother. 1988;21:581-8.
14.
Schaefler S. Methicillin-resistant strains of Staphylococcus aureus resistant to quinolones. J Clin Microbiol. 1989;27:335-6.
15.
Wolff MBure A, and Pathe J. Evolution des résistances bactériennes à la péfloxacine dans le service de réanimation de l'hôpital Claude Bernard. In: Pocidalo JJ, Vachon F, Régnier B, eds. Les Nouvelles Quinolones. Paris: Editions Arnette; 1985:213-25.
16.
Strausbaugh LJacobson CSewell D, and Ward T. Emergence of ciprofloxacin (Cip) resistance during an outbreak caused by methicillin-resistant Staphylococcus aureus (MRSA) in a nursing home care unit (NHCU) [Abstract no. 1257]. Program Abstracts 29th Interscience Conference on Antimicrobial Agents and Chemotherapy, 1989.
17.
Oppenheim BHartley JLee W, and Burnie J. Outbreak of coagulase negative staphylococcus highly resistant to ciprofloxacin in a leukaemia unit. BMJ. 1989;299:294-7.
18.
Kotilainen PNikoskelainen J, and Huovinen P. Emergence of ciprofloxacin-resistant coagulase-negative staphylococcal skin flora in immunocompromised patients receiving ciprofloxacin. J Infect Dis. 1990;161:41-4.
19.
Shalit IBerger SGorea A, and Frimerman H. Widespread quinolone resistance among methicillin-resistant Staphylococcus aureus isolates in a general hospital. Antimicrob Agents Chemother. 1989;33:593-4.
20.
Wolfson J and Hooper D. Fluoroquinolone antimicrobial agents. Clin Microbiol Rev. 1989;2:378-424.
21.
Yoshida HBogaki MNakamura SUbukata K, and Konno M. Nucleotide sequence and characterization of the Staphylococcus aureus nor A gene, which confers resistance to quinolones. J Bacteriol. 1990;172:6942-9.
22.
Sreedharan SOram MJensen BPeterson L, and Fisher L. DNA gyrase gyrA mutations in ciprofloxacin-resistant strains of Staphylococcus aureus: close similarity with quinolone resistance mutations in Escherichia coli. J Bacteriol. 1990;172:7260-2.
23.
Rohner PHerter CAuckenthaler RPechère JWaldvogel F, and Lew D. Synergistic effect of quinolones and oxacillin on methicillin-resistant Staphylococcus species. Antimicrob Agents Chemother. 1989;33:2037-41.
24.
Kaatz GSeo SBarriere SAlbrecht L, and Rybak M. Ciprofloxacin and rifampin, alone and in combination, for therapy of experimental Staphylococcus aureus endocarditis. Antimicrob Agents Chemother. 1989;33:1184-7.
25.
Dworkin RSande MLee B, and Chambers H. Treatment of rightsided Staphylococcus aureus endocarditis in intravenous drug users with ciprofloxacin and rifampicin. Lancet. 1989;2:1071-3.
26.
Desplaces NGutmann LCarlet JGuibert J, and Acar J. The new quinolones and their combinations with other agents for therapy of severe infections. J Antimicrob Chemother. 1986;17:25-39.

Information & Authors

Information

Published In

cover image Annals of Internal Medicine
Annals of Internal Medicine
Volume 114Number 51 March 1991
Pages: 424 - 426

History

Published in issue: 1 March 1991
Published online: 1 December 2008

Keywords

Authors

Affiliations

Michele Trucksis, PhD, MD
Massachusetts General Hospital Harvard Medical School Boston, MA 02114-2696
David C. Hooper, MD
Massachusetts General Hospital Harvard Medical School Boston, MA 02114-2696
John S. Wolfson, MD, PhD
Massachusetts General Hospital Harvard Medical School Boston, MA 02114-2696

Metrics & Citations

Metrics

Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. For an editable text file, please select Medlars format which will download as a .txt file. Simply select your manager software from the list below and click Download.

For more information or tips please see 'Downloading to a citation manager' in the Help menu.

Format





Download article citation data for:
Michele Trucksis, David C. Hooper, John S. Wolfson. Emerging Resistance to Fluoroquinolones in Staphylococci: An Alert. Ann Intern Med.1991;114:424-426. doi:10.7326/0003-4819-114-5-424

View More

Get Access

Login Options:
Purchase

You will be redirected to acponline.org to sign-in to Annals to complete your purchase.

Create your Free Account

You will be redirected to acponline.org to create an account that will provide access to Annals.

View options

PDF/ePub

View PDF/ePub

Related in ACP Journals

Media

Figures

Other

Tables

Share

Share

Copy the content Link

Share on social media