Article
1 January 1985

Persisting Illness and Fatigue in Adults with Evidence of Epstein-Barr Virus Infection

Publication: Annals of Internal Medicine
Volume 102, Number 1

Abstract

Clinical, serologic, virologic, and immunologic evaluations for 31 adults with chronic illness and fatigue suggested that 23 had persisting Epstein-Barr virus infection. Among these 23 patients, cellular immune mechanisms were generally normal, but 4 had mild immunoglobulin deficiencies. However, 20 patients had abnormal serologic profiles specific for Epstein-Barr virus shown by significantly elevated titers of antibodies to the viral capsid antigen or early antigen, or by a deficiency of late-appearing antibodies. In 11 of 15 patients tested, circulating immune complexes were found. Circulating interferon was not found in 18 patients tested, but the activity of 2-5 oligoadenylate synthetase, an interferon-induced enzyme, was increased in 5 patients studied. Of 19 patients, 18 had persisting suppressor T-cell activity typically found in patients recovering from acute infectious mononucleosis. We believe that the Epstein-Barr virus may be associated with chronic illness in adults.

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Information & Authors

Information

Published In

cover image Annals of Internal Medicine
Annals of Internal Medicine
Volume 102Number 11 January 1985
Pages: 7 - 16

History

Published in issue: 1 January 1985
Published online: 1 December 2008

Keywords

Authors

Affiliations

STEPHEN E. STRAUS, M.D.
Bethesda, Maryland; Rochester, Minnesota; New York, New York; and Philadelphia, Pennsylvania
GIOVANNA TOSATO, M.D.
Bethesda, Maryland; Rochester, Minnesota; New York, New York; and Philadelphia, Pennsylvania
GARY ARMSTRONG, B.S.M.T.
Bethesda, Maryland; Rochester, Minnesota; New York, New York; and Philadelphia, Pennsylvania
THOMAS LAWLEY, M.D.
Bethesda, Maryland; Rochester, Minnesota; New York, New York; and Philadelphia, Pennsylvania
OLIVIA T. PREBLE, Ph.D.
Bethesda, Maryland; Rochester, Minnesota; New York, New York; and Philadelphia, Pennsylvania
WERNER HENLE, M.D.
Bethesda, Maryland; Rochester, Minnesota; New York, New York; and Philadelphia, Pennsylvania
RICHARD DAVEY, M.D.
Bethesda, Maryland; Rochester, Minnesota; New York, New York; and Philadelphia, Pennsylvania
GARY PEARSON, Ph.D.
Bethesda, Maryland; Rochester, Minnesota; New York, New York; and Philadelphia, Pennsylvania
JAY EPSTEIN, M.D.
Bethesda, Maryland; Rochester, Minnesota; New York, New York; and Philadelphia, Pennsylvania
IRENA BRUS, M.D.
Bethesda, Maryland; Rochester, Minnesota; New York, New York; and Philadelphia, Pennsylvania
R. MICHAEL BLAESE, M.D.
Bethesda, Maryland; Rochester, Minnesota; New York, New York; and Philadelphia, Pennsylvania
▸From the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Division of Virology, Office of Biologic Research and Review, Food and Drug Administration, Dermatology Branch and Metabolism Branch, National Cancer Institute, and the Clinical Center, National Institutes of Health, Bethesda, Maryland; Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Microbiology, Mayo Clinic, Rochester, Minnesota; Beth Israel Medical Center and Joint Diseases North General Hospital, New York, New York; and the Division of Virology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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STEPHEN E. STRAUS, GIOVANNA TOSATO, GARY ARMSTRONG, et al. Persisting Illness and Fatigue in Adults with Evidence of Epstein-Barr Virus Infection. Ann Intern Med.1985;102:7-16. doi:10.7326/0003-4819-102-1-7

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